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Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis
(MDPI, 2020)
info:eu-repo/semantics/article,
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ...
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions
(Frontiers Media, 2022)
Artículo / Artikulua,
One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over ...
New in vivo approach to broaden the thioredoxin family interactome in chloroplasts
(MDPI, 2022)
Artículo / Artikulua,
Post-translational redox modifications provide an important mechanism for the control of major cellular processes. Thioredoxins (Trxs), which are key actors in this regulatory mechanism, are ubiquitous proteins that catalyse ...
Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism
(Oxford University Press, 2022)
Artículo / Artikulua,
Synaptic impairment might precede neuronal degeneration in Parkinson’s disease. However, the intimate mechanisms
altering synaptic function by the accumulation of presynaptic α-synuclein in striatal dopaminergic terminals ...
Improvement of cognitive function in wild-type and Alzheimer's disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells
(Frontiers Media, 2023)
Artículo / Artikulua,
A complex network of interactions exists between the olfactory, immune and central nervous systems. In this work we intend to investigate this connection through the use of an immunostimulatory odorant like menthol, analyzing ...
Deregulated transcription and proteostasis in adult mapt knockout mouse
(MDPI, 2023)
Artículo / Artikulua,
Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with ...
Biomarkers of delirium risk in older adults: a systematic review and meta-analysis
(Frontiers Media, 2023)
Artículo / Artikulua,
Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the ...
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
(BMC, 2023)
Artículo / Artikulua,
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture ...
Proteostatic modulation in brain aging without associated Alzheimer's disease-and age-related neuropathological changes
(Impact Journals, 2023)
Artículo / Artikulua,
Aims: (Phospho)proteomics of old-aged subjects without cognitive or behavioral symptoms, and without ADneuropathological changes and lacking any other neurodegenerative alteration will increase understanding about
the ...
Metschnikowia pulcherrima as an efficient biocontrol agent of Botrytis cinerea infection in apples: unraveling protection mechanisms through yeast proteomics
(Elsevier, 2023)
Artículo / Artikulua,
The results obtained in this study show that the Mp-30 strain of Metschnikowia pulcherrima is able to completely
prevent Botrytis cinerea infection in apples, which is a major postharvest disease of fruits throughout the ...