Listar Artículos de revista DCS - OZS Aldizkari artikuluak por tema "Parkinson's disease"

Alteration in the cerebrospinal fluid lipidome in Parkinson’s disease: a post-mortem pilot study

Fernández Irigoyen, Joaquín

; Cartas-Cejudo, Paz; Iruarrizaga-Lejarreta, Marta; Santamaría, Enrique (MDPI, 2021) Artículo / Artikulua

Lipid metabolism is clearly associated to Parkinson’s disease (PD). Although lipid homeostasis has been widely studied in multiple animal and cellular models, as well as in blood derived from PD individuals, the cerebrospinal ...

Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit

Belloso Iguerategui, Arantzazu; Zamarbide, Marta; Merino Galán, Leyre; Rodríguez Chinchilla, Tatiana; Gago, Belén; Santamaría, Enrique; Fernández Irigoyen, Joaquín

; Cotman, Carl W.; Prieto, G. Aleph; Quiroga Varela, Ana; Rodríguez Oroz, María Cruz (Oxford University Press, 2023) Artículo / Artikulua

Learning and memory mainly rely on correct synaptic function in the hippocampus and other brain regions. In Parkinson’s disease, subtle cognitive deficits may even precede motor signs early in the disease. Hence, we set ...

Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models

Vinueza-Gavilanes, Rodrigo; Bravo-González, Jorge Juan; Basurco, Leyre; Boncristiani, Chiara; Fernández Irigoyen, Joaquín

; Santamaría, Enrique; Marcilla, Irene; Pérez Mediavilla, Alberto; Luquin, María Rosario; Vales, Africa; González-Aseguinolaza, Gloria; Aymerich, María Soledad; Aragón, Tomás; Arrasate, Montserrat (Elsevier, 2023) Artículo / Artikulua

Synucleinopathies are a group of neurodegenerative diseases without effective treatment characterized by the abnormal aggregation of alpha-synuclein (aSyn) protein. Changes in levels or in the amino acid sequence of aSyn ...

Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism

Merino Galán, Leyre; Jiménez Urbieta, Haritz; Zamarbide, Marta; Rodríguez Chinchilla, Tatiana; Belloso Iguerategui, Arantzazu; Santamaría, Enrique; Fernández Irigoyen, Joaquín

; Aiastui, Ana; Doudnikoff, Evelyne.; Bézard, Erwan; Ouro, Alberto; Knafo, Shira; Gago, Belén; Quiroga Varela, Ana; Rodríguez Oroz, María Cruz (Oxford University Press, 2022) Artículo / Artikulua

Synaptic impairment might precede neuronal degeneration in Parkinson’s disease. However, the intimate mechanisms altering synaptic function by the accumulation of presynaptic α-synuclein in striatal dopaminergic terminals ...