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The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity
(Springer Nature, 2021)
info:eu-repo/semantics/article,
Background: improving cancer immunotherapy long-term clinical benefit is a major priority. It has become apparent that multiple axes of immune suppression restrain the capacity of T cells to provide anti-tumour activity ...
Tackling the biological meaning of the human olfactory bulb dyshomeostatic proteome across neurological disorders: an integrative bioinformatic approach
(MDPI, 2021)
info:eu-repo/semantics/article,
Olfactory dysfunction is considered an early prodromal marker of many neurodegenerative diseases. Neuropathological changes and aberrant protein aggregates occur in the olfactory bulb (OB), triggering a tangled cascade of ...
The Spanish version of the child medical fear questionnaire: cross-cultural adaptation and validation
(MDPI, 2021)
info:eu-repo/semantics/article,
Having valid and reliable tools that help health professionals to assess fear in children undergoing medical procedures is essential to offer humanised and quality of care in the paediatric population. The aim of this study ...
Adolescents adjudicated for sexual offending: differences between sexual reoffenders and sexual non-reoffenders
(SAGE Publications, 2021)
info:eu-repo/semantics/article,
Although a very small group of adolescents adjudicated for sexual offending (ASO) will persist into adulthood, the use of official records of sexual recidivism after long-term follow-up periods underrates the repetition ...
Impact of COVID-19 confinement on physical activity and sedentary behaviour in Spanish university students: role of gender
(MDPI, 2021)
info:eu-repo/semantics/article,
During the COVID-19 pandemic, entire populations were instructed to live in home-confinement to prevent the expansion of the disease. Spain was one of the countries with the strictest conditions, as outdoor physical activity ...
Physical activity, sedentary behavior, sleep and self-regulation in Spanish preschoolers during the COVID-19 lockdown
(MDPI, 2021)
info:eu-repo/semantics/article,
Background: A better understanding of the effects of the lockdown on lifestyle behaviors may help to guide the public health response to COVID-19 at a national level and to update the global strategy to respond COVID-19 ...
Prevalence and differential profile of patients with substance use disorder who have suffered physical and/or sexual abuse
(SAGE, 2021)
Artículo / Artikulua,
Patients with substance use disorder (SUD) who undergo treatment present a high prevalence of lifetime physical and/or sexual abuse. Studies about this phenomenon and the specific needs of patients with a history of abuse ...
Predictive factors for anxiety during blood sampling and insertion of peripheral intravenous catheters in paediatric patients in Spain
(Elsevier, 2021)
Artículo / Artikulua,
Introduction: Invasive procedures for diagnosis purposes such as venepuncture and peripheral venous catheter insertion are painful procedures that cause great stress for paediatric patients. The objective of this study is ...
Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model
(MDPI, 2021)
info:eu-repo/semantics/article,
Maraviroc (MVC), a CCR5 antagonist, reduces liver fibrosis, injury and tumour burden in mice fed a hepatocarcinogenic diet, suggesting it has potential as a cancer therapeutic. We investigated the effect of MVC on liver ...
Variability in the control of type 2 diabetes in primary care and its association with hospital admissions for vascular events. The APNA study
(MDPI, 2021)
info:eu-repo/semantics/article,
Type 2 diabetes (T2D) is associated with increased cardiovascular morbidity, mortality, and hospital admissions. This study aimed to analyze how the differences in delivered care (variability of glycosylated hemoglobin ...