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Glucose levels as a mediator of the detrimental effect of abdominal obesity on relative handgrip strength in older adults
dc.creator | Pérez Sousa, Miguel A. | es_ES |
dc.creator | Pozo Cruz, Jesús del | es_ES |
dc.creator | Cano Gutiérrez, Carlos Alberto | es_ES |
dc.creator | Izquierdo Redín, Mikel | es_ES |
dc.creator | Ramírez Vélez, Robinson | es_ES |
dc.date.accessioned | 2021-02-04T12:24:41Z | |
dc.date.available | 2021-02-04T12:24:41Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2077-0383 (Electronic) | |
dc.identifier.uri | https://hdl.handle.net/2454/39137 | |
dc.description.abstract | Excess central adiposity accelerates the decline of muscle strength in older people. Additionally, hyperglycemia, independent of associated comorbidities, is related to the loss of muscle mass and strength, and contributes to functional impairment in older adults. We studied the mediation effect of glucose levels, in the relationship between abdominal obesity and relative handgrip strength (HGS). A total of 1571 participants (60.0% women, mean age 69.1 +/- 7.0 years) from 86 municipalities were selected following a multistage area probability sampling design. Measurements included demographic and anthropometric/adiposity markers (weight, height, body mass index, and waist circumference). HGS was measured using a digital dynamometer for three sets and the mean value was recorded. The values were normalized to body weight (relative HGS). Fasting glucose was analyzed by enzymatic colorimetric methods. Mediation analyses were performed to identify associations between the independent variable (abdominal obesity) and outcomes (relative HGS), as well as to determine whether fasting glucose levels mediated the relationship between excess adiposity and relative HGS. A total of 1239 (78.8%) had abdominal obesity. Abdominal obesity had a negative effect on fasting glucose (beta = 9.04, 95%CI = 5.87 to 12.21); while fasting glucose to relative HGS was inversely related (beta = -0.003, 95%CI = -0.005 to -0.001),p< 0.001. The direct effect of abdominal obesity on relative HGS was statistically significant (beta = -0.069, 95%CI = -0.082 to -0.057),p< 0.001. Lastly, fasting glucose levels mediates the detrimental effect of abdominal obesity on relative HGS (indirect effect beta = -0.002, 95%CI = -0.004 to -0.001),p< 0.001. Our results suggest that the glucose level could worsen the association between abdominal obesity status and lower HGS. Thus, it is plausible to consider fasting glucose levels when assessing older adults with excess adiposity and/or suspected loss of muscle mass. | en |
dc.description.sponsorship | This study is part of a larger project that has been funded by a Colciencias y Ministerio de Salud y la Protección Social de Colombia (The SABE Study ID 2013, no. 764). M.I. is also funded in part by a research grant PI17/01814 of the Ministerio de Economía, Industria y Competitividad (ISCIII, FEDER). R.R.-V. was funded in part by a Postdoctoral Fellowship Resolution ID 420/2019 of the Universidad Pública de Navarra. | en |
dc.format.extent | 12 p. | |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | MDPI | en |
dc.relation.ispartof | Journal of Clinical Medicine, 2020, 9(8), 2323 | en |
dc.rights | © The Author(s). 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Fat mass | en |
dc.subject | Obesity | en |
dc.subject | Muscle strength | en |
dc.subject | Physical function | en |
dc.subject | Diabetes | en |
dc.title | Glucose levels as a mediator of the detrimental effect of abdominal obesity on relative handgrip strength in older adults | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.identifier.doi | 10.3390/jcm9082323 | |
dc.relation.publisherversion | https://doi.org/10.3390/jcm9082323 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua | es |
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changes were made. The images or other third party material in this article are included in the article's Creative Commons
licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons
licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain
permission directly from the copyright holder. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the
data made available in this article, unless otherwise stated in a credit line to the data.