The influence of the accessory genome on bacterial pathogen evolution
Fecha
2011Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
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doi.org/10.4161/mge.1.1.16432
Resumen
Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing host immunity. Molecular arms-races have been a strong driving force for the evolution of pathogenicity, with pathogens often encoding overlapping or redundant functions, such as type III protein secret ...
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Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing host immunity. Molecular arms-races have been a strong driving force for the evolution of pathogenicity, with pathogens often encoding overlapping or redundant functions, such as type III protein secretion effectors and hosts encoding ever more sophisticated immune systems. The pathogens’ frequent exposure to other microbes, either in their host or in the environment, provides opportunities for the acquisition or interchange of mobile genetic elements. These DNA elements accessorize the core genome and can play major roles in shaping genome structure and altering the complement of virulence factors. Here, we review the different mobile genetic elements focusing on the more recent discoveries and highlighting their role in shaping bacterial pathogen evolution. [--]
Materias
Horizontal gene transfer,
Plasmid,
Transposon,
Integron,
Genomic island,
Insertion sequence,
Bacteriophage,
Virulence,
Animal pathogen,
Plant pathogen,
Pathogenicity islands
Publicado en
Mobile Genetic Elements 1:1, 55-65; May/June, 2011
Departamento
Universidad Pública de Navarra. Departamento de Producción Agraria /
Nafarroako Unibertsitate Publikoa. Nekazaritza Ekoizpena Saila
Versión del editor
Entidades Financiadoras
J.M. Thanks the Spanish Ministerio de Ciencia e Innovación (AGL2008-05311-C02-01) for financial support. B.A.V. acknowledges funding from the National Science Foundation (Award IOS 0746501).