Periostin plasma levels and changes on physical and cognitive capacities in community-dwelling older adults
Fecha
2023Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.1093/gerona/glac226
Resumen
Periostin, involved in extracellular matrix development and support, has been shown to be elevated in senescent tissues and fibrotic states,
transversal signatures of aging. We aimed to explore associations between plasma periostin and physical and cognitive capacity evolution
among older adults. Our hypothesis was that higher levels of plasma periostin will be associated with worse physical an ...
[++]
Periostin, involved in extracellular matrix development and support, has been shown to be elevated in senescent tissues and fibrotic states,
transversal signatures of aging. We aimed to explore associations between plasma periostin and physical and cognitive capacity evolution
among older adults. Our hypothesis was that higher levels of plasma periostin will be associated with worse physical and mental capacities
along time. Analyses included 1 096 participants (mean age = 75.3 years ± 4.4; 63.9% women) from the Multidomain Alzheimer Preventive
Trial. Periostin levels (pg/mL) were measured in plasma collected at year 1. Periostin was used in continuous variable, and as a dichotomous
variable highest quartile (POSTN+) versus lowest 3 quartiles (POSTN−) were used. Outcomes were measured annually over 4 years and
included: gait speed (GS), short physical performance battery (SPPB) score, 5-times sit-to-stand test (5-STS), and handgrip strength (HS) as
physical and cognitive composite z-score (CCS) and the Mini-Mental State Examination (MMSE) as cognitive endpoints. Plasma periostin
as a continuous variable was associated with the worsening of physical and cognitive capacities over 4 years of follow-up, specifically the
SPPB score, the 5-STS, and CCS in full-adjusted models. POSTN+ was associated with worse evolution in the physical (GS: [β = −0.057, 95%
confidence interval (CI) = −0.101, −0.013], SPPB score [β = −0.736, 95% CI = −1.091, −0.381], 5-STS [β = 1.681, 95% CI = 0.801, 2.561])
as well as cognitive (CCS [β = −0.215, 95% CI = −0.335, −0.094]) domains compared to POSTN− group. No association was found with HS
or the MMSE score. Our study showed for the first time that increased plasma periostin levels were associated with declines in both physical
and cognitive capacities in older adults over a 4-year follow-up. Further research is needed to evaluate whether periostin might be used as a
predictive biomarker of functional decline at an older age. [--]
Materias
Aging biomarker,
Extracellular matrix,
Healthy aging
Editor
Oxford University Press
Publicado en
Journal of Gerontology: Biological Sciences & Medical Sciences, 78(3), 424-432
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
This work was supported by grants from the Gerontopple of Toulouse, the French Ministry of Health (PHRC 2008, 2009), Pierre Fabre Research Institute (manufacturer of the omega-3 supplement), ExonHit Therapeutics SA, and Avid Radiopharmaceuticals Inc. The data-sharing activity was supported by the Association Monegasque pour la Recherche sur la maladie d'Alzheimer (AMPA) and the INSERM-University of Toulouse III UMR 1295 Unit. The present work was performed in the context of the Inspire Program, a research platform sup-ported by grants from the Region Occitanie/Pyrenees-Mediterranee (Reference number: 1901175) and the European Regional Development Fund (ERDF; Project number: MP0022856). This study received funds from Alzheimer Prevention in Occitania and Catalonia (APOC Chair of Excellence-Inspire Program)