Maximal oxidative capacity during exercise is associated with muscle power output in patients with long coronavirus disease 2019 (COVID-19) syndrome. A moderation analysis.
Fecha
2023Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
Impacto
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10.1016/j.clnesp.2023.10.009
Resumen
Background & aims: Long COVID syndrome (LCS) involves persistent symptoms experienced by many
patients after recovering from coronavirus disease 2019 (COVID-19). We aimed to assess skeletal muscle
energy metabolism, which is closely related to substrate oxidation rates during exercise, in patients with
LCS compared with healthy controls. We also examined whether muscle power output mediates th ...
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Background & aims: Long COVID syndrome (LCS) involves persistent symptoms experienced by many
patients after recovering from coronavirus disease 2019 (COVID-19). We aimed to assess skeletal muscle
energy metabolism, which is closely related to substrate oxidation rates during exercise, in patients with
LCS compared with healthy controls. We also examined whether muscle power output mediates the
relationship between COVID-19 and skeletal muscle energy metabolism.
Methods: In this cross-sectional study, we enrolled 71 patients with LCS and 63 healthy controls. We
assessed clinical characteristics such as body composition, physical activity, and muscle strength. We
used cardiopulmonary exercise testing to evaluate substrate oxidation rates during graded exercise. We
performed statistical analyses to compare group characteristics and peak fat oxidation differences based
on power output.
Results: The two-way analysis of covariance (ANCOVA) results, adjusted for covariates, showed that the
patients with LCS had lower absolute maximal fatty acid oxidation (MFO), relative MFO/fat free mass
(FFM), absolute carbohydrates oxidation (CHox), relative CHox/FFM, and oxygen uptake (V__O2) at
maximum fat oxidation (g min1
) than the healthy controls (P < 0.05). Moderation analysis indicated that
muscle power output significantly influenced the relationship between LCS and reduced peak fat
oxidation (interaction b ¼ 0.105 [95% confidence interval 0.174; 0.036]; P ¼ 0.026). Therefore, when
muscle power output was below 388 W, the effect of the LCS on MFO was significant (62% in our study
sample P ¼ 0.010). These findings suggest compromised mitochondrial bioenergetics and muscle function, represented by lower peak fat oxidation rates, in the patients with LCS compared with the healthy
controls.
Conclusion: The patients with LCS had lower peak fat oxidation during exercise compared with the
healthy controls, potentially indicating impairment in skeletal muscle function. The relationship between
peak fat oxidation and LCS appears to be mediated predominantly by muscle power output. Additional
research should continue investigating LCS pathogenesis and the functional role of mitochondria. [--]
Materias
Muscle strength,
Muscle mass,
Post-acute COVID-19 syndrome,
Fatty acid oxidation
Editor
Elsevier
Publicado en
Clinical Nutrition, 2023, vol. 58
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
The EXER-COVID study was supported by «Proyectos de I+D+i» de los Programas Estatales de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del Sistema de I + D + i Orientada a los Retos de la Sociedad, en el marco del Plan Estatal de Investigación Científica y Técnica y de Innovación 2017–2020 (PID2020-113098RB-I00)