Villaño Valencia, Débora
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Villaño Valencia
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Débora
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Agronomía, Biotecnología y Alimentación
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IS-FOOD. Research Institute on Innovation & Sustainable Development in Food Chain
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Publication Open Access Antioxidant, anti-inflammatory, and microbial-modulating activities of nutraceuticals and functional foods 2019(Hindawi, 2020) Peluso, Ilaria; Villaño Valencia, Débora; Chen, Oliver; Palmery, Maura; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura; Institute on Innovation and Sustainable Development in Food Chain - ISFOODThis issue includes original and review articles covering many aspects of the antioxidant and antiinflammatory activities of nutraceuticals, functional foods, and bioactive compounds from various origins.Publication Open Access Non-provitamin A and provitamin A carotenoids as immunomodulators: recommended dietary allowance, therapeutic index, or personalized nutrition?(Hindawi, 2018) Toti, Elisabetta; Chen, Oliver; Palmery, Maura; Villaño Valencia, Débora; Peluso, Ilaria; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura; Institute on Innovation and Sustainable Development in Food Chain - ISFOODVegetables and fruits contain non-provitamin A (lycopene, lutein, and zeaxanthin) and provitamin A (β-carotene, β-cryptoxanthin, and α-carotene) carotenoids. Within these compounds, β-carotene has been extensively studied for its health benefits, but its supplementation at doses higher than recommended intakes induces adverse effects. β-Carotene is converted to retinoic acid (RA), a well-known immunomodulatory molecule. Human interventions suggest that β-carotene and lycopene at pharmacological doses affect immune functions after a depletion period of low carotenoid diet. However, these effects appear unrelated to carotenoids and retinol levels in plasma. Local production of RA in the gut-associated lymphoid tissue, as well as the dependency of RA-induced effects on local inflammation, suggests that personalized nutrition/supplementation should be considered in the future. On the other hand, the differential effect of RA and lycopene on transforming growth factor-beta suggests that lycopene supplementation could improve immune functions without increasing risk for cancers. However, such preclinical evidence must be confirmed in human interventions before any recommendations can be made.Publication Open Access Antioxidant, anti-inflammatory, and microbial-modulating activities of nutraceuticals and functional foods(Hindawi, 2017) Peluso, Ilaria; Magrone, Thea; Villaño Valencia, Débora; Chen, Oliver; Palmery, Maura; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura; Institute on Innovation and Sustainable Development in Food Chain - ISFOODThis special issue highlights the importance of using different methodological approaches in order to clarify the mechanisms of the potential health effects of nutraceuticals.Publication Open Access Antioxidant, anti-inflammatory, and microbial-modulating activities of nutraceuticals and functional foods 2018(Hindawi, 2018) Peluso, Ilaria; Villaño Valencia, Débora; Chen, Oliver; Palmery, Maura; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura; Institute on Innovation and Sustainable Development in Food Chain - ISFOODWe hope that this special issue adds knowledge of preclinical data of the potential health effects of nutraceuticals. However, these results only provide supports for future studies, particularly human trials, but not give indications for supplementation.