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Gene-exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial

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dc.contributor.authorPlaza Florido, Abel
dc.contributor.authorEsteban Cornejo, Irene
dc.contributor.authorMora González, José
dc.contributor.authorTorres-López, Lucía V.
dc.contributor.authorOsuna Prieto, Francisco J.
dc.contributor.authorGil Cosano, José J.
dc.contributor.authorRadom-Aizik, Shlomit
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.authorAltmäe, Signe
dc.contributor.authorOrtega, Francisco B.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2024-05-28T14:35:14Z
dc.date.issued2023
dc.date.updated2024-05-28T13:32:58Z
dc.description.abstractWe investigated the interaction between a genetic score and an exercise intervention on brain health in children with overweight/obesity. One hundred one children with overweight/obesity (10.0 ± 1.5 yr, 59% girls) were randomized into a 20-wk combined exercise intervention or a control group. Several cognitive and academic outcomes were measured with validated tests. Hippocampal volume was quantified using magnetic resonance imaging. Six brain health-related polymorphisms [rs6265 (BDNF), rs2253206 (CREB1), rs2289656 (NTRK2), rs4680 (COMT), rs429358, and rs7412 (APOE)] were genotyped. Cognitive flexibility and academic skills improved significantly more in the exercise than in the control group only in the children with a “favorable” genetic profile [mean z-score, 0.41–0.67 (95% CI 0.11 to 1.18)], yet not in those with “less favorable” genetic profile. An individual response analysis showed that children responded to exercise in cognitive flexibility only in the “genetically favorable” group [i.e., 62% of them had a meaningful (≥0.2 Cohen d) increase in the exercise group compared with only 25% in the control group]. This finding was consistent in per-protocol and intention-to-treat analyses (P = 0.01 and P = 0.03, respectively). The results were not significant or not consistent for the rest of outcomes studied. Our findings suggest that having a more favorable genetic profile makes children with overweight/obesity more responsive to exercise, particularly for cognitive flexibility.en
dc.description.sponsorshipThe project was mainly funded by the Spanish Ministry of Economy and Competitiveness (Reference DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP) and by the Andalusian Operational Programme supported with European Regional Development Funds (ERDF in English, FEDER in Spanish, projects ref: B-CTS-355-UGR18 and A-CTS-614-UGR20) and Junta de Andalucia (P20_00158). Grant Endo-Map PID2021-12728OB-100 funded by MCIN/AEI/10.13039/501100011033 and ERFD A way of making Europe; Grant RYC-2016-21199, funded by MCIN/AEI/ 10.13039/501100011033 and by ESF Investing in your future. This study was supported in part by the Pediatric Exercise and Genomics Research Center (PERC) Systems Biology Fund. A.P.-F. is supported in part by NIH Grant No.: U01 TR002004 (REACH project). I.E.-C. is supported by the Spanish Ministries of Economy and Competitiveness (RTI2018-095284-J-100), and Science and Innovation (RYC2019-027287-I). F.J.O.-P. is supported by Margarita Salas program (Programa de recualificación del profesorado Universitario, Ministerio de Universidades). Additional support was obtained from the Unit of Excellence on EXERNET Research Network on Exercise and Health (DEP2005-00046/ACTI; 09/UPB/ 19; 45/UPB/20; 27/UPB/21); Alicia Koplowitz Foundation. This study has been partially funded by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR.en
dc.embargo.lift2024-09-23
dc.embargo.terms2024-09-23
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPlaza-Florido, A., Esteban-Cornejo, I., Mora-Gonzalez, J., Torres-Lopez, L. V., Osuna-Prieto, F. J., Gil-Cosano, J. J., Radom-Aizik, S., Labayen, I., Ruiz, J. R., Altmäe, S., Ortega, F. B. (2023) Gene-exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial. Journal of Applied Physiology, 135(4), 775-785. https://doi.org/10.1152/japplphysiol.00435.2023.en
dc.identifier.doi10.1152/japplphysiol.00435.2023
dc.identifier.issn8750-7587
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/48203
dc.language.isoengen
dc.publisherAmerican Physiological Societyen
dc.relation.ispartofJournal of Applied Physiology 135(4), 3023, 775-785en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2013-47540-R/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2016-79512-Ren
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2017-91544-EXPen
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI//PID2021-12728OB-100en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI//RYC-2016-21199en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095284-J-I00/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI//RYC2019-027287-Ien
dc.relation.publisherversionhttps://doi.org/10.1152/japplphysiol.00435.2023
dc.rights© 2023 the American Physiological Society.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectCognitionen
dc.subjectFitnessen
dc.subjectGeneticsen
dc.subjectPediatricsen
dc.subjectPhysical activityen
dc.titleGene-exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión aceptada / Onetsi den bertsioaes
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscoveryb36e2b1d-3088-4089-806e-fd3040e9583a

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