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Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts

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dc.contributor.authorJurado Fasoli, Lucas
dc.contributor.authorSánchez Delgado, Guillermo
dc.contributor.authorAlcántara Alcántara, Juan Manuel
dc.contributor.authorAcosta, Francisco M.
dc.contributor.authorSánchez Sánchez, Rocío
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorMartínez Téllez, Borja
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2024-05-23T12:07:40Z
dc.date.available2024-05-23T12:07:40Z
dc.date.issued2024
dc.date.updated2024-05-23T11:34:35Z
dc.description.abstractBackground: There is a subset of individuals with overweight/obesity characterized by a lower risk of cardiometabolic complications, the so-called metabolically healthy overweight/obesity (MHOO) phenotype. Despite the relatively higher levels of subcutaneous adipose tissue and lower visceral adipose tissue observed in individuals with MHOO than individuals with metabolically unhealthy overweight/obesity (MUOO), little is known about the differences in brown adipose tissue (BAT). Methods: This study included 53 young adults (28 women) with a body mass index (BMI) ¿25 kg/m2 which were classified as MHOO (n = 34) or MUOO (n = 19). BAT was assessed through a static 18F-FDG positron emission tomography/computed tomography scan after a 2-h personalized cooling protocol. Energy expenditure, skin temperature, and thermal perception were assessed during a standardized mixed meal test (3.5 h) and a 1-h personalized cold exposure. Body composition was assessed by dual-energy x-ray absorptiometry, energy intake was determined during an ad libitum meal test and dietary recalls, and physical activity levels were determined by a wrist-worn accelerometer. Findings: Participants with MHOO presented higher BAT volume (+124%, P = 0.008), SUVmean (+63%, P = 0.001), and SUVpeak (+133%, P = 0.003) than MUOO, despite having similar BAT mean radiodensity (P = 0.354). In addition, individuals with MHOO exhibited marginally higher meal-induced thermogenesis (P = 0.096) and cold-induced thermogenesis (+158%, P = 0.050). Moreover, MHOO participants showed higher supraclavicular skin temperature than MUOO during the first hour of the postprandial period and during the cold exposure, while no statistically significant differences were observed in other skin temperature parameters. We observed no statistically significant differences between MHOO and MUOO in thermal perception, body composition, outdoor ambient temperature exposure, resting metabolic rate, energy intake, or physical activity levels. Interpretation: Adults with MHOO present higher BAT volume and activity than MUOO. The higher meal- and cold-induced thermogenesis and cold-induced supraclavicular skin temperature are compatible with a higher BAT activity. Overall, these results suggest that BAT presence and activity might be linked to a healthier phenotype in young adults with overweight or obesity.es_ES
dc.description.sponsorshipThe study was supported by the Junta de Andalucía, Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección General de Investigación y Transferencia del Conocimiento (ref. P18-RT-4455, ref. SOMM17/6107/UGR, and DOC 01151) and European Regional Development Funds (ERDF), the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393), and PTA-12264, Retos de la Sociedad (DEP2016-79512-R), the Spanish Ministry of Education (FPU13/04365, FPU15/04059 and FPU19/01609), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES). G.SD is supported by a Marie Sklodowska-Curie Actions-Individual Fellowship (101028941; Horizon 2020, European Commission). B.MT is supported by a grant for the requalification of the Spanish university system from the Ministry of Universities of the Government of Spain, funded by the European Union, NextGeneration EU (María Zambrano program, reference RR _C_2021_04). J.M.A.A. is supported by the Juan de la Cierva-Formación Grant FJC2020-044453-I funded by MCIN/AEI/10.13039/501100011033 and 'European Union NextGeneration EU/PRTR'es_ES
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dc.format.mimetypeapplication/msworden
dc.identifier.citationJurado-Fasoli, L., Sanchez-Delgado, G., Alcantara, J. M. A., Acosta, F. M., Sanchez-Sanchez, R., Labayen, I., Ortega, F. B., Martinez-Tellez, B., Ruiz, J. R. (2024) Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts. eBioMedicine, 100, 1-15. https://doi.org/10.1016/j.ebiom.2023.104948.es_ES
dc.identifier.doi10.1016/j.ebiom.2023.104948es_ES
dc.identifier.issn2352-3964es_ES
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/48187
dc.language.isoengen
dc.publisherElsevieres_ES
dc.relation.ispartofeBioMedicine (2024), vol. 100, 104948es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F01393/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement///PTA-12264en
dc.relation.projectIDinfo:eu-repo/grantAgreement///DEP2016-79512-Ren
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU13%2F04365/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU15%2F04059/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement///FPU19%2F01609en
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/101028941en
dc.relation.publisherversionhttps://doi.org/10.1016/j.ebiom.2023.104948es_ES
dc.rights© 2023 The Author(s). This is an open access article under the CC BY-NC-ND license.es_ES
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.subjectAdaptive thermogenesises_ES
dc.subjectBrown fates_ES
dc.subjectCardiometabolic healthes_ES
dc.subjectMetabolismes_ES
dc.subjectThermoregulationes_ES
dc.titleAdults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterpartses_ES
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublication81010fc5-9a1b-44dd-8cfe-933acda93159
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscoveryb36e2b1d-3088-4089-806e-fd3040e9583a

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