Long-term outcomes of first-admission psychosis: a naturalistic 21-year follow-up study of symptomatic, functional and personal recovery and their baseline predictors

Simple item page
dc.contributor.authorPeralta Martín, Víctor
dc.contributor.authorGarcía de Jalón, Elena
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorPeralta, David
dc.contributor.authorJanda-Galán, Lucía
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorSEGPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-01-30T17:34:14Z
dc.date.available2024-01-30T17:34:14Z
dc.date.issued2022
dc.date.updated2024-01-30T16:56:24Z
dc.description.abstractThis study was aimed at characterizing long-term outcomes of first-admission psychosis and examining their baseline predictors. Participants were assessed at baseline for 38 candidate predictors and re-assessed after a median follow-up of 21 years for symptomatic, functional, and personal recovery. Associations between the predictors and the outcomes were examined using univariate and multivariate Cox regression models. At baseline, 623 subjects were assessed for eligibility, 510 met the inclusion/exclusion criteria and 243 were successfully followed-up (57.3% of the survivors). At follow-up, the percentages of subjects achieving symptomatic, functional, and personal recovery were 51.9%, 52.7%, and 51.9%, respectively; 74.2% met at least one recovery criterion and 32.5% met all three recovery criteria. Univariate analysis showed that outcomes were predicted by a broad range of variables, including sociodemographics, familial risk, early risk factors, premorbid functioning, triggering factors, illness-onset features, neurological abnormalities, deficit symptoms and early response to treatment. Many of the univariate predictors became nonsignificant when entered into a hierarchical multivariate model, indicating a substantial degree of interdependence. Each single outcome component was independently predicted by parental socioeconomic status, family history of schizophrenia spectrum disorders, early developmental delay, childhood adversity, and mild drug use. Spontaneous dyskinesia/parkinsonism, neurological soft signs and completion of high school remained specific predictors of symptomatic, functional, and personal outcomes, respectively. Predictors explained between 27.5% and 34.3% of the variance in the outcomes. In conclusion, our results indicate a strong potential for background and first-episode characteristics in predicting long-term outcomes of psychotic disorders, which may inform future intervention research.en
dc.description.sponsorshipThe study was funded by the Carlos III Health Institute (FEDER Funds) from the Spanish Ministry of Economy and Competitiveness (grant number PI16/02148) and the Regional Government of Navarra (grant number 31/17).en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationPeralta, V., García de Jalón, E., Moreno-Izco, L., Peralta, D., Janda, L., Sánchez-Torres, A. M., Cuesta, M. J., SEGPEPs Group (2022) Long-term outcomes of first-admission psychosis: A naturalistic 21-year follow-up study of symptomatic, functional and personal recovery and their baseline predictors. Schizophrenia Bulletin, 48(3), 631-642. https://doi.org/10.1093/schbul/sbab145.en
dc.identifier.doi10.1093/schbul/sbab145
dc.identifier.issn0586-7614
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/47270
dc.language.isoengen
dc.publisherOxford University Pressen
dc.relation.ispartofSchizophrenia Bulletin 48(3), 631–642, 2022en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI16%2F02148/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//31%2F17)/
dc.relation.publisherversionhttps://doi.org/10.1093/schbul/sbab145
dc.rights© The Author(s) 2022. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectFirst-episode psychosisen
dc.subjectRisk factorsen
dc.subjectPrognosisen
dc.subjectFull remissionen
dc.titleLong-term outcomes of first-admission psychosis: a naturalistic 21-year follow-up study of symptomatic, functional and personal recovery and their baseline predictorsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Peralta2022_longterm_outcomes_postprint.pdf
Size:
849.57 KB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Peralta_LongtermOutcomes_MatCompl.docx
Size:
67.27 KB
Format:
Microsoft Word XML
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.78 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DCS - OZS Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak