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Understanding LAG-3 Signaling

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dc.contributor.authorChocarro de Erauso, Luisa
dc.contributor.authorBlanco, Ester
dc.contributor.authorZuazo Ibarra, Miren
dc.contributor.authorArasanz Esteban, Hugo
dc.contributor.authorBocanegra Gondán, Ana Isabel
dc.contributor.authorFernández Rubio, Leticia
dc.contributor.authorMorente Sancho, Pilar
dc.contributor.authorFernández Hinojal, Gonzalo
dc.contributor.authorEchaide Górriz, Míriam
dc.contributor.authorGarnica, Maider
dc.contributor.authorRamos, Pablo
dc.contributor.authorVera García, Ruth
dc.contributor.authorKochan, Grazyna
dc.contributor.authorEscors Murugarren, David
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2022-01-17T12:48:03Z
dc.date.available2022-01-17T12:48:03Z
dc.date.issued2021
dc.description.abstractLymphocyte activation gene 3 (LAG-3) is a cell surface inhibitory receptor with multiple biological activities over T cell activation and effector functions. LAG-3 plays a regulatory role in immunity and emerged some time ago as an inhibitory immune checkpoint molecule comparable to PD-1 and CTLA-4 and a potential target for enhancing anti-cancer immune responses. LAG-3 is the third inhibitory receptor to be exploited in human anti-cancer immunotherapies, and it is considered a potential next-generation cancer immunotherapy target in human therapy, right next to PD-1 and CTLA-4. Unlike PD-1 and CTLA-4, the exact mechanisms of action of LAG-3 and its relationship with other immune checkpoint molecules remain poorly understood. This is partly caused by the presence of non-conventional signaling motifs in its intracellular domain that are different from other conventional immunoregulatory signaling motifs but with similar inhibitory activities. Here we summarize the current understanding of LAG-3 signaling and its role in LAG-3 functions, from its mechanisms of action to clinical applications.en
dc.description.sponsorshipThe Oncoimmunology group is funded by the Spanish Association against Cancer (AECC, PROYE16001ESCO); Instituto de Salud Carlos III (ISCIII)-FEDER project grants (FIS PI17/02119, FIS PI20/00010, COV20/00000, and TRANSPOCART ICI19/00069); a Biomedicine Project grant from the Department of Health of the Government of Navarre (BMED 050-2019); Strategic projects from the Department of Industry, Government of Navarre (AGATA, Ref 0011-1411-2020-000013; LINTERNA, Ref. 0011-1411-2020-000033; DESCARTHES, 0011-1411-2019-000058); European Project Horizon 2020 Improved Vaccination for Older Adults (ISOLDA; ID: 848166); Crescendo Biologics Ltd.en
dc.format.extent20 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.3390/ijms22105282
dc.identifier.issn1422-0067
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/41811
dc.language.isoengen
dc.publisherMDPI
dc.relation.ispartofInternational Journal of Molecular Sciences, 22 (10), 5282
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/848166en
dc.relation.publisherversionhttp://doi.org/10.3390/ijms22105282
dc.rights© 2021 by the authors. Creative Commons Attribution 4.0 International Licenseen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectLAG-3en
dc.subjectImmune checkpointen
dc.subjectCancer signalingen
dc.subjectImmunotherapyen
dc.subjectTargeted therapyen
dc.titleUnderstanding LAG-3 Signalingen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dspace.entity.typePublication
relation.isAuthorOfPublicationfe5c362e-3c0c-4edb-aa2e-0de27c815ad2
relation.isAuthorOfPublication193d800d-c38c-4627-b9d8-d29435d8214c
relation.isAuthorOfPublication.latestForDiscoveryfe5c362e-3c0c-4edb-aa2e-0de27c815ad2

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