Albumin-based optical and electrochemical biosensors for PFAS detection: a comparison
| dc.contributor.author | Moro, G. | |
| dc.contributor.author | Chiavaioli, Francesco | |
| dc.contributor.author | Zubiate Orzanco, Pablo | |
| dc.contributor.author | Del Villar, Ignacio | |
| dc.contributor.author | Baldini, Francesco | |
| dc.contributor.author | De Wael, K. | |
| dc.contributor.author | Moretto, L. M. | |
| dc.contributor.author | Giannetti, Ambra | |
| dc.contributor.department | Ingeniería Eléctrica, Electrónica y de Comunicación | es_ES |
| dc.contributor.department | Ingeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritza | eu |
| dc.contributor.department | Institute of Smart Cities - ISC | en |
| dc.date.accessioned | 2024-10-02T11:52:45Z | |
| dc.date.available | 2024-10-02T11:52:45Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2024-10-02T11:47:02Z | |
| dc.description.abstract | The widespread industrial use of per- and polyfluoroalkyl substances (PFAS) have engendered the release of these manmade chemicals in the environment with harmful effects on animal and human health. To monitor PFAS levels in drinking waters, sensitive and versatile sensing strategies are urgently required. Since many perfluoroalkyl carboxylic acids, such as perfluorooctanoic acid (PFOA), are fatty acid-mimic, delipidated human serum albumin (HSA) can be applied as biorecognition element for the design of novel PFAS sensors. Here, two albumin-based biosensing strategies are described and compared: i) a lossy mode resonance (LMR) fiber optic one and ii) an impedimetric portable one developed on screen-printed electrodes. In both biosensing platforms, HSA was covalently immobilized via EDC/NHS chemistry using the carboxylic moieties of the polymeric layers previously deposited at the transducer surface. Afterwards, the conformational changes related to the formation of HSA/PFOA complex were followed considering: i) the LMR spectral shifts for the optical platform and ii) the changes of absolute impedance for the impedimetric one. The performance and future developments of both PFOA biosensors are discussed. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Moro, G., Chiavaioli, F., Zubiate, P., Del Villar, I., Baldini, F., De Wael, K., Moretto, L. M., Giannetti, A. (2023) Albumin-based optical and electrochemical biosensors for PFAS detection: a comparison. In Di Francia, G., Di Natale C. (Eds.), Sensors and microsystems: Proceedings of AISEM 2022 (pp. 1-15). Springer. https://doi.org/10.1007/978-3-031-25706-3_1. | |
| dc.identifier.doi | 10.1007/978-3-031-25706-3_1 | |
| dc.identifier.isbn | 978-3-031-25705-6 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/51942 | |
| dc.language.iso | eng | |
| dc.publisher | Springer | |
| dc.relation.ispartof | Di Francia, G.; Di Natale, C. (Eds.). Sensors and microsystems: Proceedings of AISEM 2022. Cham: Springer; 2023. p. 1-15 978-3-031-25705-6 | |
| dc.relation.publisherversion | https://doi.org/10.1007/978-3-031-25706-3_1 | |
| dc.rights | © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 | |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.subject | Biosensor | en |
| dc.subject | D-shaped fiber optics | en |
| dc.subject | Delipidated human serum albumin (HSA) | en |
| dc.subject | Lossy mode resonance (LMR) fiber optic | en |
| dc.subject | Per- and polyfluoroalkyl substances (PFAS) | en |
| dc.subject | Perfluorooctanoic acid (PFOA) | en |
| dc.title | Albumin-based optical and electrochemical biosensors for PFAS detection: a comparison | en |
| dc.type | info:eu-repo/semantics/conferenceObject | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dspace.entity.type | Publication | |
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| relation.isAuthorOfPublication | 4af62af3-50fe-47ee-a17c-bd4ffb52ebe3 | |
| relation.isAuthorOfPublication.latestForDiscovery | 5362455c-45c7-4da4-9627-218e3bc1b1f1 |