Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study

dc.contributor.authorLaosa, Olga
dc.contributor.authorTopinkova, Eva
dc.contributor.authorBourdel Marchasson, Isabelle
dc.contributor.authorVellas, Bruno
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.authorPaolisso, Giuseppe
dc.contributor.authorHardman, Timothy C.
dc.contributor.authorZeyfang, Andrej
dc.contributor.authorPedraza, Laura
dc.contributor.authorCarnicero Carreño, José Antonio
dc.contributor.authorRodríguez Mañas, Leocadio
dc.contributor.authorSinclair, Alan J.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2025-03-25T10:06:54Z
dc.date.available2025-03-25T10:06:54Z
dc.date.issued2025-02-14
dc.date.updated2025-03-25T09:54:50Z
dc.description.abstractAims: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after 18 months of intervention. Methods: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18–24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). Results: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried’s frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3–5.4; p = 0.009 and OR 1.9; 95%CI 1.1 3.1; p = 0.02, respectively). IG participants more frequently improved 1 point in SPPB score (OR 1.85; 95%CI 1.09–3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. Conclusions: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.en
dc.description.sponsorshipThis research was supported by European Commission, 7th Framework Programme (Contract No 278803) and CIBERFES (CB16/10/00464).
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationLaosa, O., Topinkova, E., Bourdel-Marchasson, I., Vellas, B., Izquierdo, M., Paolisso, G., Hardman, T., Zeyfang, A., Pedraza, L., Carnicero, J. A., Rodríguez-Mañas, L., Sinclair, A. J. (2025). Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study. The Journal of Nutrition, Health and Aging, 29(4), 1-7. https://doi.org/10.1016/j.jnha.2025.100512.
dc.identifier.doi10.1016/j.jnha.2025.100512
dc.identifier.issn1279-7707
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53809
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofThe Journal of Nutrition, Health and Aging (2025), vol. 29, núm. 4, 100512
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/FP7/278803/
dc.relation.publisherversionhttps://doi.org/10.1016/j.jnha.2025.100512
dc.rights© 2025 Published by Elsevier Masson SAS on behalf of SERDI Publisher. This is an open access article under the CC BY-NC-ND license.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFrailtyen
dc.subjectOlder peopleen
dc.subjectDiabetesen
dc.subjectClinical trialen
dc.subjectFunctional impairmenten
dc.titleLong-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationef73585d-4750-4f56-9d4f-0d759232dbca
relation.isAuthorOfPublication.latestForDiscoveryef73585d-4750-4f56-9d4f-0d759232dbca

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