Nanosensor for detection of glucose
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- MICYT//TIC2003-00909/
- MICYT// TIC2001-0877-C02-02/
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Abstract
A novel fibre-optic sensor sensitive to glucose has been designed based on electrostatic self-assembly method. The polycation of the structure is a mixture of poly(allylamine hydrochloride) (PAH) and Prussian Blue, whereas the polyanion is well-known enzyme glucose oxidase (GOx). The range of glucose concentration that can be measured is submilimolar and is located between 0.1 and 2 mM. Measures are based on a new detection scheme based on the slope of the change of signal produced by injection of glucose, yielding to a linear response. The sensor responses in a PH range between 4 and 7.4, which includes the physiological PH of blood. Some rules for estimation of the refractive index of the material deposited and the thickness of bilayers are also given.
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