Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study
dc.contributor.author | Ni, Jiaqi | |
dc.contributor.author | Nishi, Stephanie K. | |
dc.contributor.author | Babio, Nancy | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Basterra Gortari, Francisco Javier | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Castañer, Olga | |
dc.contributor.author | Martínez, J. Alfredo | |
dc.contributor.author | Alonso Gómez, Ángel M. | |
dc.contributor.author | Wärnberg, Julia | |
dc.contributor.author | Vioque, Jesús | |
dc.contributor.author | Romaguera, Dora | |
dc.contributor.author | López Miranda, José | |
dc.contributor.author | Estruch, Ramón | |
dc.contributor.author | Tinahones, Francisco J. | |
dc.contributor.author | Santos Lozano, José Manuel | |
dc.contributor.author | Serra-Majem, Lluis | |
dc.contributor.author | Cano Ibáñez, Noemí | |
dc.contributor.author | Tur, Josep A. | |
dc.contributor.author | Fernández-García, José Manuel | |
dc.contributor.author | Pintó, Xavier | |
dc.contributor.author | Delgado Rodríguez, Miguel | |
dc.contributor.author | Matía-Martín, Pilar | |
dc.contributor.author | Vidal, Josep | |
dc.contributor.author | Vázquez, Clotilde | |
dc.contributor.author | Daimiel, Lidia | |
dc.contributor.author | Fernández-Aranda, Fernando | |
dc.contributor.author | Ruiz Canela, Miguel | |
dc.contributor.author | Mestres Solà, Cristina | |
dc.contributor.author | Portolés, Olga | |
dc.contributor.author | Sala Vila, Aleix | |
dc.contributor.author | García-Rios, Antonio | |
dc.contributor.author | Compañ-Gabucio, Laura María | |
dc.contributor.author | Gómez-Gracia, Enrique | |
dc.contributor.author | Zulet, María Ángeles | |
dc.contributor.author | Chaplin, Alice | |
dc.contributor.author | Casas, Rosa | |
dc.contributor.author | Martínez Diz, Silvia | |
dc.contributor.author | Tojal-Sierra, Lucas | |
dc.contributor.author | Gómez Pérez, Ana María | |
dc.contributor.author | Toledo, Estefanía | |
dc.contributor.author | Ríos, Santiago | |
dc.contributor.author | Ortega Azorín, Carolina | |
dc.contributor.author | Torre, Rafael de la | |
dc.contributor.author | Peña-Orihuela, Patricia J. | |
dc.contributor.author | García de la Hera, Manuela | |
dc.contributor.author | Sayón-Orea, Carmen | |
dc.contributor.author | Malcampo, Mireia | |
dc.contributor.author | Salas-Salvadó, Jordi | |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.date.accessioned | 2023-10-09T11:22:57Z | |
dc.date.available | 2023-10-09T11:22:57Z | |
dc.date.issued | 2023 | |
dc.date.updated | 2023-10-09T09:37:23Z | |
dc.description.abstract | Background: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited and inconsistent regarding the potential benefits of nuts for cognitive function. Objective: To prospectively evaluate the association between nut consumption and 2-y changes in cognitive performance in older adults at cognitive decline risk. Methods: A total of 6,630 participants aged 55 to 75 y (mean age 65.04.9 y, 48.4% women) with overweight/obesity and metabolic syndrome completed a validated semi-quantitative food frequency questionnaire and a comprehensive battery of neuropsychological tests at baseline and a 2-y follow-up. Composite cognitive scores were used to assess global, general, attention, and executive function domains. Nut consumption was categorized as <1, 1 to <3, 3 to <7, and 7 servings/wk (1 serving¼30 g). Multivariable-adjusted linear regression models were fitted to assess associations between baseline nut consumption and 2-y cognitive changes. Results: Nut consumption was positively associated with 2-y changes in general cognitive function (P-trend <0.001). Compared with participants consuming <1 serving/wk of nuts, those categorized as consuming 3 to <7 and 7 servings/wk showed more favorable changes in general cognitive performance (β z-score [95% CI] ¼ 0.06 [0.00,0.12] and 0.13 [0.06,0.20], respectively). No significant changes were observed in the multivariableadjusted models for other cognitive domains assessed. Conclusion: Frequent nut consumption was associated with a smaller decline in general cognitive performance over 2 y in older adults at risk of cognitive decline. Randomized clinical trials to verify our findings are warranted. | en |
dc.description.sponsorship | This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the European Regional Development Fund (6 coordinated FIS projects leaded by JS-S and JoV, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/ 00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/ 01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/ 00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/ 00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/ 00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/ 00886, PI20/01158); the Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad física Cohorte PREDIMED-Plus grant and the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the European Research Council (Advanced Research Grant 2014–2019; agreement #340918); grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/ 017 and PROMETEO/2021/021 grants from the Consellería de Innovacion, Universidades, Ciencia y Sociedad digital de la Generalitat Valenciana; Grant PID2019-108858RB-I00 funded by AEI 10.13039/ 501100011033 and by “ERDF A way of making Europe”; the SEMERGEN grant; the AICO/2021/347 grants from the Generalitat Valenciana. This research was also partially funded by EU-H2020 Grants (Eat2beNICE/ H2020-SFS-2016-2); and the Horizon 2020 PRIME study (Prevention and Remediation of Insulin Multimorbidity in Europe; grant agreement #847879). JN is supported by a predoctoral grant from Ministerio de Ciencia, Innovacion y Universidades (FPU 20/ 00385). SKN is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR). JS-S, the senior author of this paper, was partially supported by ICREA under the ICREA Academia program. | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Ni, J., Nishi, S. K., Babio, N., Ros, E., Basterra-Gortari, F. J., Corella, D., O, C., Martínez, J. A., Alonso-Gómez, Á. M., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F. J., Santos-Lozano, J. M., Serra-Majem, L., Cano-Ibáñez, N., Tur, J. A., … Salas-Salvadó, J. (2023). Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: A cohort study. The American Journal of Clinical Nutrition, 118(2), 360-368. https://doi.org/10.1016/j.ajcnut.2023.05.032 | en |
dc.identifier.doi | 10.1016/j.ajcnut.2023.05.032 | |
dc.identifier.issn | 0002-9165 | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/46481 | |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.relation.ispartof | The American Journal of Clinical Nutrition 18(2023) 360-368 | en |
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dc.relation.publisherversion | https://doi.org/10.1016/j.ajcnut.2023.05.032 | |
dc.rights | © 2023 The Author(s). This is an open access article under the CC BY-NC-ND license. | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Aging | en |
dc.subject | Cognition | en |
dc.subject | Cognitive decline | en |
dc.subject | Nuts | en |
dc.subject | Older people | en |
dc.subject | Unsaturated fatty acids | en |
dc.title | Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study | en |
dc.type | info:eu-repo/semantics/article | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dspace.entity.type | Publication | |
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