Predicted vitamin D levels and risk of depression in the SUN Project: a prospective cohort study
| dc.contributor.author | Sabiao, Thaís da Silva | |
| dc.contributor.author | Valer-Martínez, Ana | |
| dc.contributor.author | Sayón-Orea, Carmen | |
| dc.contributor.author | Sánchez Villegas, María Almudena | |
| dc.contributor.author | Pons, Juan José | |
| dc.contributor.author | Cardoso Carraro, Júlia Cristina | |
| dc.contributor.author | Martínez González, Miguel Ángel | |
| dc.contributor.author | Bes-Rastrollo, Maira | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.contributor.department | Institute on Innovation and Sustainable Development in Food Chain - ISFOOD | en |
| dc.date.accessioned | 2025-03-06T12:44:32Z | |
| dc.date.available | 2025-03-06T12:44:32Z | |
| dc.date.issued | 2024-09-30 | |
| dc.date.updated | 2025-03-06T12:34:05Z | |
| dc.description.abstract | The current study aimed to investigate the association between predicted vitamin D status and depression in a prospective Spanish cohort of university graduates. The SUN Project is a dynamic cohort study designed to investigate multiple aspects of health and lifestyle. Participants were asked to complete a comprehensive questionnaire consisting of 556 items, that included a validated food-frequency questionnaire. Participants initially free of depression were classified as incident cases if they reported a medical diagnosis of depression during follow-up. Serum vitamin D levels were predicted by a previously validated equation. Vitamin D deficiency was defined as vitamin D levels below 20 ng/mL. Cox models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI). We included 15,175 Spanish university graduates [mean (SD) age: 36.9 year (11.5)] followed-up for a median of 12.7 years. Among 192,976 person-years of follow-up, we identified 753 incident cases of depression. Participants with vitamin D deficiency had a 27% higher risk of depression as compared to those with vitamin D sufficiency (HR: 1.27, 95% CI: 1.09¿1.48; p = 0.002) after adjusting for potential confounders. Furthermore, a significant effect modification by female sex was observed with higher depression risks associated with vitamin D deficiency in women than in men (p for interaction = 0.034). In educated middle-aged Spanish adults, we observed a direct association between vitamin D deficiency and the risk of depression, that was stronger among women. | en |
| dc.description.sponsorship | This work was carried out with the support of CNPq, the National Council for Scientific and Technological Development -Brazil. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Da Silva Sabião, T., Valer-Martínez, A., Sayon-Orea, C., Sánchez-Villegas, A., Pons, J. J., Cardoso Carraro J. C., Martinez-Gonzalez, M. Á., Bes-Rastrollo, M. (2024). Predicted vitamin D levels and risk of depression in the SUN Project: a prospective cohort study. Journal of Psychiatric Research, 179, 314-321. https://doi.org/10.1016/j.jpsychires.2024.09.034. | |
| dc.identifier.doi | 10.1016/j.jpsychires.2024.09.034 | |
| dc.identifier.issn | 0022-3956 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/53681 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartof | Journal of Psychiatric Research 179 (2024) 314-321 | |
| dc.relation.publisherversion | https://doi.org/10.1016/j.jpsychires.2024.09.034 | |
| dc.rights | © 2024 The Authors. This is an open access article under the CC BY-NC-ND license. | |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Depression | en |
| dc.subject | Prospective studies | en |
| dc.subject | SUN cohort | en |
| dc.subject | Sun exposure | en |
| dc.subject | Vitamin D | en |
| dc.title | Predicted vitamin D levels and risk of depression in the SUN Project: a prospective cohort study | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | ae8afd07-1f10-4da5-8582-93b90a18aa88 | |
| relation.isAuthorOfPublication.latestForDiscovery | ae8afd07-1f10-4da5-8582-93b90a18aa88 |