Publication: Mediterranean diet-based intervention to improve depressive symptoms: analysis of the PREDIDEP randomized trial
| dc.contributor.author | Cabrera Suárez, Beatriz | |
| dc.contributor.author | Hernández-Fleta, José L. | |
| dc.contributor.author | Molero, Patricio | |
| dc.contributor.author | González Pinto, Ana | |
| dc.contributor.author | Lahortiga Ramos, Francisca | |
| dc.contributor.author | Cabrera, Claudio | |
| dc.contributor.author | Chiclana Actis, Carlos | |
| dc.contributor.author | Sánchez Villegas, María Almudena | |
| dc.contributor.author | PREDI-DEP investigators | |
| dc.contributor.department | Institute on Innovation and Sustainable Development in Food Chain - ISFOOD | en |
| dc.date.accessioned | 2024-05-10T17:06:33Z | |
| dc.date.available | 2024-05-10T17:06:33Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2024-05-10T16:32:18Z | |
| dc.description.abstract | Background:The effect of an intervention based on Mediterranean diet on reducing recurrencerisk or subsyndromal depressive symptoms in recovered depressed patients has not beenexplored.Methods:The PREDIDEP study was a two-year randomized trial designed to assess the effect of theMediterranean Diet enriched with extra virgin olive oil on depression recurrence. At baseline and atfour, eight, 16, 20, and 24 months of follow-up, depressive symptoms were evaluated through theBeck Depression inventory. Cox regression analysis wasfitted to assess the role of dietaryintervention on the risk of depression recurrence. Mixed effects linear models were used toassess changes in depressive subsyndromal symptoms according to the intervention.Results::After two years of intervention, the dietary intervention group (n= 103) compared to thecontrol group (n= 93) showed no differences regarding depression recurrence risk as mainoutcome. As secondary outcomes, an improvement of depressive symptoms was yielded at four(−2.15; 95% CI =−4.00 to−0.29) and eight months (−2.42; 95% CI =−4.17 to−0.67) in theintervention group, with no changes in control group. Moreover, at 20 months, significantdifferences were found between groups (−3.35; 95% CI =−6.08 to−0.61).Conclusions: An intervention with Mediterranean diet in patients with previous depressiveepisodes might contribute to the reduction of depressive subsyndromal symptoms. | en |
| dc.description.sponsorship | This study is externally funded by the Spanish Ministry of Economy and Competitiveness (ISCIII), grant no. PI16/01274. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Cabrera-Suárez, B. M., Hernández-Fleta, J. L., Molero, P., González-Pinto, A., Lahortiga, F., Cabrera, C., Chiclana-Actis, C., Sánchez-Villegas, A., PREDI-DEP investigators (2023) Mediterranean diet-based intervention to improve depressive symptoms: Analysis of the PREDIDEP randomized trial. Nutritional Neuroscience, 1-12. https://doi.org/10.1080/1028415X.2023.2283290. | en |
| dc.identifier.doi | 10.1080/1028415X.2023.2283290 | |
| dc.identifier.issn | 1028-415X | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/48107 | |
| dc.language.iso | eng | en |
| dc.publisher | Taylor and Francis Group | en |
| dc.relation.ispartof | Nutritional Neuroscience 2023, 1-12 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F01274/ES/ | en |
| dc.relation.publisherversion | https://doi.org/10.1080/1028415X.2023.2283290 | |
| dc.rights | © 2023 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. | en |
| dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Clinical trial | en |
| dc.subject | Depression | en |
| dc.subject | Mediterranean diet | en |
| dc.subject | Olive oil | en |
| dc.title | Mediterranean diet-based intervention to improve depressive symptoms: analysis of the PREDIDEP randomized trial | en |
| dc.type | Artículo / Artikulua | es |
| dc.type | info:eu-repo/semantics/article | en |
| dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
| dc.type.version | info:eu-repo/semantics/publishedVersion | en |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | ae8afd07-1f10-4da5-8582-93b90a18aa88 | |
| relation.isAuthorOfPublication.latestForDiscovery | ae8afd07-1f10-4da5-8582-93b90a18aa88 |