Tailored prevention of functional decline through a multicomponent exercise program in hospitalized oncogeriatric patients: study protocol for a randomized clinical trial

dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.authorArrazubi, Virginia
dc.contributor.authorZambom Ferraresi, Fabíola
dc.contributor.authorMorilla Ruiz, Idoia
dc.contributor.authorLópez Sáez de Asteasu, Mikel
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorCasa Marín, Antón de la
dc.contributor.authorOllo Martínez, Iranzu
dc.contributor.authorGorospe-García, Itziar
dc.contributor.authorGurruchaga Sotés, Ibon
dc.contributor.authorGalbete Jiménez, Arkaitz
dc.contributor.authorCedeño Veloz, Bernardo Abel
dc.contributor.authorMartín-Nevado, L.
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.authorVera García, Ruth
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentEstadística, Informática y Matemáticases_ES
dc.contributor.departmentEstatistika, Informatika eta Matematikaeu
dc.date.accessioned2024-05-16T16:40:18Z
dc.date.available2024-05-16T16:40:18Z
dc.date.issued2023
dc.date.updated2024-05-16T15:45:30Z
dc.description.abstractBACKGROUND: Cancer mostly affects older adults, causing a wide variety of diagnostic and therapeutic dilemmas. One of the most important moments in cancer patients is the hospitalization period, in which older patients usually remain bedridden for many hours and this may lead to the appearance of sarcopenia and disability. METHODS: We present the research protocol for a randomized controlled trial that will analyze whether an intervention applied to older patients (≥ 65 years) who are hospitalized for acute medical conditions in an Oncology Department improves function. A total of 240 hospitalized older patients will be recruited in the Hospital Universitario de Navarra, Pamplona, Spain, and they will be randomized. The intervention consists of a multicomponent exercise training program that will take place for 4 consecutive days (2 sessions/day). The control group will receive usual hospital care, which will include physical rehabilitation when needed. The primary end point will be the change in functional capacity from baseline to hospital discharge, assessed with the Short Physical Performance Battery (SPPB). Secondary end points will be changes in cognitive and mood status, quality of life, fatigue, strength (dynamic and handgrip), pain, nutrition, length of stay, falls, readmission rate and mortality at 3 months after discharge. RESULTS: Basal data of the patients included in the RCT are described. The foreseen recruitment will not be achieved due to the context of the Covid pandemic and the significantly different responses observed during the clinical trial in oncogeriatric patients compared to our previous experience in older adults hospitalized for medical reasons. DISCUSSION: If our hypothesis is correct and shows that a multicomponent, individualized and progressive exercise program is an effective therapy for improving the capacity of acutely hospitalized older patients compared to usual care, a change in the current system of hospitalization may be justified in oncogeriatric patients.en
dc.description.sponsorshipOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationMartínez-Velilla, N., Arrazubi, V., Zambom-Ferraresi, F., Morilla-Ruiz, I., Sáez de Asteasuu, M. L., Ramírez-Vélez, R., Zambom-Ferraresi, F., De la Casa-Marín, A., Ollo-Martínez, I., Gorospe-García, I., Gurruchaga-Sotés, I., Galbete, A., Cedeño-Veloz, B. A., Martín-Nevado, L., Izquierdo, M., Vera, R. (2023) Tailored prevention of functional decline through a multicomponent exercise program in hospitalized oncogeriatric patients: Study protocol for a randomized clinical trial. Journal of Nutrition, Health and Aging, 27(10), 911-918. https://doi.org/10.1007/s12603-023-1977-y.en
dc.identifier.doi10.1007/s12603-023-1977-y
dc.identifier.issn1279-7707
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/48131
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofJournal of Nutrition, Health and Aging 27(10), 2023, 911-918en
dc.relation.publisherversionhttps://doi.org/10.1007/s12603-023-1977-y
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCanceren
dc.subjectDisabilityen
dc.subjectFunctional capacityen
dc.subjectHospitalizationen
dc.subjectMulticomponent exerciseen
dc.subjectOncogeriatricen
dc.titleTailored prevention of functional decline through a multicomponent exercise program in hospitalized oncogeriatric patients: study protocol for a randomized clinical trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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