Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children

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dc.contributor.authorBravo, Carolina
dc.contributor.authorMericq, Verónica
dc.contributor.authorPereira, Ana
dc.contributor.authorCorvalán, Camila
dc.contributor.authorTobar, Hugo E.
dc.contributor.authorMiranda, José Patricio
dc.contributor.authorSantos Martín, José Luis
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2025-04-11T16:22:13Z
dc.date.available2025-04-11T16:22:13Z
dc.date.issued2024-02-02
dc.date.updated2025-04-11T15:53:08Z
dc.description.abstractObjective: To assess the association between leptin/adiponectin ratio (LAR) and insulin resistance surrogates in prepubertal children. Subjects and methods: Study based on data from the Growth and Obesity Chilean Cohort Study (GOCS) involving 968 Chilean prepubertal children. Plasma insulin, leptin, and adiponectin were determined by immunoassays. Several common insulin resistance surrogates were calculated, including the homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride/HDL cholesterol index, triglyceride-glucose (TyG) index, and the TyG index corrected for body mass index (BMI; TyG-BMI) and waist circumference (WC; TyG-WC). Associations among variables were assessed using multiple linear and logistic regression analysis. Results: There was a significant direct association between plasma leptin and LAR with BMI z-score but no association between plasma adiponectin and adiposity. After adjustments for sex and age, LAR was significantly associated with all insulin resistance surrogates (which were categorized using the 75th percentile as the cutoff point), with the TyG-WC index emerging as the surrogate with the highest magnitude of association (odds ratio [OR] 2.44, 95% confidence interval [CI] 2.05-2.9). After additional adjustment for BMI z-score, only the association between LAR and TyG-WC remained significant (OR 1.64, 95% CI 1.27-2.12). Conclusion: Plasma leptin and LAR were strongly associated with several common insulin resistance surrogates in prepubertal children, most notably with the TyG-WC index. Associations between LAR and insulin resistance indexes were mainly driven by the effect of plasma leptin, which is also directly associated with increased adiposity.en
dc.description.sponsorshipThis research work was supported by grants from the Chilean Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT Projects 1090252 and 1150416) and funding from the Chilean Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) numbers 21171744 and 242190355.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBravo, C., Mericq, V., Pereira. A., Corvalán, C., Tobar, H. E., Miranda, J. P., Santos, J. L. (2024) Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children. Archives of Endocrinology and Metabolism, 68, 220353-220353. https://doi.org/10.20945/2359-4292-2022-0353.
dc.identifier.doi10.20945/2359-4292-2022-0353
dc.identifier.issn2359-3997
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53952
dc.language.isoeng
dc.publisherBrazilian Society of Endocrinology and Metabolism – SBEM
dc.relation.ispartofArchives of Endocrinology and Metabolism, 2024, 68, 1-10, e220353
dc.relation.publisherversionhttps://doi.org/10.20945/2359-4292-2022-0353
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdiponectinen
dc.subjectInsulin resistanceen
dc.subjectLeptinen
dc.subjectLeptin/adiponectin ratioen
dc.titleAssociation between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal childrenen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationa52c0775-f788-4e86-bfbb-a94121c2fbd4
relation.isAuthorOfPublication.latestForDiscoverya52c0775-f788-4e86-bfbb-a94121c2fbd4

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