Exercise training in long COVID: the EXER-COVID trial

Simple item page
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorOteiza Olaso, Julio
dc.contributor.authorLegarra Gorgoñón, Gaizka
dc.contributor.authorOscoz Ochandorena, Sergio
dc.contributor.authorGarcía Alonso, Nora
dc.contributor.authorGarcía Alonso, Yesenia
dc.contributor.authorCorrea Rodríguez, María
dc.contributor.authorSoto-Mota, Adrian
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentCiencias humanas y de la educaciónes_ES
dc.contributor.departmentGiza eta Hezkuntza Zientziakeu
dc.date.accessioned2025-01-14T19:51:27Z
dc.date.issued2024-11-22
dc.date.updated2025-01-14T19:10:48Z
dc.description.abstractBackground: the post-COVID-19 condition is a novel condition for which guidelines recommend supervised exercise, but evidence guiding safe and effective interventions is limited. The aim of this study was to investigate the effects of a tailored exercise program (EXER-COVID 5 trial) on cardiorespiratory fitness, muscle strength, long COVID symptoms, cognitive performance, quality of life, depression, and psychological distress. Methods: this crossover study included 100 participants with post-COVID-19 conditions (mean 8 age 48 years; 68% women) at a single center in Spain from March 1, 2021, to September 30, 2022. Participants were randomized 1:1 to 6 weeks of muscle power resistance training (PRT) followed by 6 weeks of usual care (Group 1 [AB], n=50) or 6 weeks of usual care followed by 6 weeks of muscle power RT (Group 2 [BA], n=50). Results: the intervention significantly improved the peak VO2 by 2.10 mL/kg/min [95% CI 1.25 to 2.94], P<0.001. Per-protocol analyses revealed similar results (2.40 mL/kg/min [95% CI 1.56 to 3.25]), P<0.001. No carry-over or period effects were detected. After power PRT, strength (1RM) was improved for pectoral press, bilateral leg-press, knee extension, and back press (P<0.001). Significant decreases were found in psychological distress scores (P<0.001). The intervention also improved quality of life (P=0.041), cognitive capabilities (P=0.014) and cognitive performance (P=0.036). Furthermore, the exercise program reduced seven of the 22 long-COVID symptoms, including weakness (RR= 0.75) dyspnea (RR= 0.56), hearing loss/tinnitus (RR= 0.86), change in appetite (RR= 0.84), memory loss (RR= 0.84), stress (RR= 0.80) and apathy/depression (RR= 0.80), (all Ps<0.05). Conclusions: a supervised 6-week PRT intervention program safely improved cardiorespiratory fitness, strength, and mental health in participants with post-COVID-19 conditions. These findings provide clinicians with evidence to support exercise as standard co-therapy and warrant further study.en
dc.description.sponsorshipThe EXER-COVID Crossover Study was supported by Proyectos de I+D+i de los Programas Estatales de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del Sistema de I+D+i Orientada a los Retos de la Sociedad, en el marco del Plan Estatal de Investigación Científica y Técnica y de Innovación 2017–2020 (PID2020-113098RB-I00).
dc.embargo.lift2025-11-22
dc.embargo.terms2025-11-22
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRamírez-Vélez, R., Oteiza, J., Legarra-Gorgoñon, G., Oscoz-Ochandorena, S., García-Alonso, N.: García-Alonso, Y., Correa-Rodríguez, M., Soto-Mota, A., Izquierdo, M. (2024) Exercise training in long COVID: the EXER-COVID trial. European Heart Journal, 1-6. https://doi.org/10.1093/eurheartj/ehae721.
dc.identifier.doi10.1093/eurheartj/ehae721
dc.identifier.issn0195-668X
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52925
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofEuropean Heart Journal 2024, ehae721
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113098RB-I00/ES/
dc.relation.publisherversionhttps://doi.org/10.1093/eurheartj/ehae721
dc.rights© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal following peer review.
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectRehabilitationen
dc.subjectPhysical activityen
dc.subjectResistance trainingen
dc.subjectLong COVIDen
dc.titleExercise training in long COVID: the EXER-COVID trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationd0c2c11e-01d0-46ff-93b4-36b11beaf269
relation.isAuthorOfPublication3e5e1516-96f8-463b-a60b-5c64275ecee1
relation.isAuthorOfPublication781851c4-4896-46e7-9df3-b32303e1db59
relation.isAuthorOfPublication2a07d963-c4bf-433d-b7f6-3453777ae723
relation.isAuthorOfPublication4e7f1a63-7c89-4d5c-a161-c278e3ba6b04
relation.isAuthorOfPublicationf5bec41f-86cd-424a-8634-ed03622150ce
relation.isAuthorOfPublicationef73585d-4750-4f56-9d4f-0d759232dbca
relation.isAuthorOfPublication.latestForDiscoveryd0c2c11e-01d0-46ff-93b4-36b11beaf269

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Ramirez_Exercise.pdf
Size:
2.2 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DCS - OZS Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak
Artículos de revista DCHE - GHZS Aldizkari artikuluak