New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry

Date

2023-02-17

Authors

Vicuña, Lucas
Barrientos, Esteban
Norambuena, Tomás
Alvares, Danilo
Gana, Juan Cristóbal
Leiva-Yamaguchi, Valeria
Meza, Cristian
Mericq, Verónica
Pereira, Ana

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Publisher

Cell Press
Acceso abierto / Sarbide irekia
Artículo / Artikulua
Versión publicada / Argitaratu den bertsioa

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Abstract

Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1:5 2:5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P = 9:8 3 10 9). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Age-AR was significantly lower (P = 0:004) by 1.94 years and BMI at AR was significantly higher (P = 0:04) by 1.2 kg/m2, in Mapuche children compared with Europeans.

Description

Keywords

Genome-wide association studies (GWAS), Body-mass index (BMI), Children

Department

Ciencias de la Salud / Osasun Zientziak / Institute on Innovation and Sustainable Development in Food Chain - ISFOOD

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Doctorate program

item.page.cita

Vicuña, L., Barrientos, E., Norambuena, T., Alvares, D., Gana, J. C., Leiva-Yamaguchi, V., Meza, C., Santos, J. L., Mericq, V., Pereira, A., Eyheramendy, S. (2023). New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry. iScience, 26(2), 1-16. https://doi.org/10.1016/j.isci.2023.106091.

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© 2023 The Author(s). This is an open access article under the CC BY-NC-ND license.

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