Randomized clinical trial: bone bioactive liquid improves implant stability and osseointegration

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dc.contributor.authorAl Madhoun, Ashraf
dc.contributor.authorMeshal, Khaled
dc.contributor.authorCarrió, Neus
dc.contributor.authorFerrés‐Amat, Eduard
dc.contributor.authorFerrés-Amat, Elvira
dc.contributor.authorBarajas Vélez, Miguel Ángel
dc.contributor.authorJiménez-Escobar, Ana Leticia
dc.contributor.authorAl-Madhoun, Areej Said
dc.contributor.authorSaber, Alaa
dc.contributor.authorAbou Alsamen, Yazan
dc.contributor.authorMarti, Carles
dc.contributor.authorAtari, Maher
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute for Multidisciplinary Research in Applied Biology - IMABen
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.date.accessioned2025-02-21T11:09:08Z
dc.date.available2025-02-21T11:09:08Z
dc.date.issued2024-10-01
dc.date.updated2025-02-21T11:00:43Z
dc.description.abstractImplant stability can be compromised by factors such as inadequate bone quality and infection, leading to potential implant failure. Ensuring implant stability and longevity is crucial for patient satisfaction and quality of life. In this multicenter, randomized, double-blind clinical trial, we assessed the impact of a bone bioactive liquid (BBL) on the Galaxy TS implant's performance, stability, and osseointegration. We evaluated the impact stability, osseointegration, and pain levels using initial stability quotient (ISQ) measurements, CBCT scans, and pain assessment post-surgery. Surface analysis was performed using scanning electron microscopy (SEM) and atomic force microscopy (AFM). In vitro studies examined the BBL's effects on dental pulp pluripotent stem cells' (DPPSCs') osteogenesis and inflammation modulation in human macrophages. All implants successfully osseointegrated, as demonstrated by the results of our clinical and histological studies. The BBL-treated implants showed significantly lower pain scores by day 7 (p < 0.00001) and improved stability by day 30 (ISQ > 62.00 ± 0.59, p < 8 × 10-7). By day 60, CBCT scans revealed an increased bone area ratio in BBL-treated implants. AFM images demonstrated the BBL's softening and wettability effect on implant surfaces. Furthermore, the BBL promoted DPPSCs' osteogenesis and modulated inflammatory markers in human primary macrophages. This study presents compelling clinical and biological evidence that BBL treatment improves Galaxy TS implant stability, reduces pain, and enhances bone formation, possibly through surface tension modulation and immunomodulatory effects. This advancement holds promise for enhancing patient outcomes and implant longevity.en
dc.description.sponsorshipThis study was funded by the OTRI project, reference number 2020907094, signed with the Public University of Navarra, Navarra, Spain.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAl Madhoun, A., Meshal, K., Carrió, N., Ferrés-Amat, E., Ferrés-Amat, E., Barajas, M., Jiménez-Escobar, A. L., Al-Madhoun, A. S., Saber, A., Abou Alsamen, Y., Marti, C., Atari, M. (2024). Randomized clinical trial: bone bioactive liquid improves implant stability and osseointegration. Journal of Functional Biomaterials, 15(10), 1-15. https://doi.org/10.3390/jfb15100293.
dc.identifier.doi10.3390/jfb15100293
dc.identifier.issn2079-4983
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53526
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofJournal of Functional Biomaterials (2024), vol. 15, núm. 10
dc.relation.publisherversionhttps://doi.org/10.3390/jfb15100293
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBBLen
dc.subjectBone bioactive liquiden
dc.subjectCBCTSen
dc.subjectDental implanten
dc.subjectGalaxy Titansure Activeen
dc.subjectISQen
dc.subjectOral wound healingen
dc.subjectPain index scoreen
dc.subjectTHERAVEXen
dc.subjectTHERAVEX Tissue Care Plusen
dc.subjectZiacomen
dc.titleRandomized clinical trial: bone bioactive liquid improves implant stability and osseointegrationen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication2e998efa-ca5a-491e-9e7f-a8fbbd0094ce
relation.isAuthorOfPublication.latestForDiscovery2e998efa-ca5a-491e-9e7f-a8fbbd0094ce

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