The risk of incident depression when assessed with the lifestyle and well-being index

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dc.contributor.authorPano, O.
dc.contributor.authorSayón-Orea, Carmen
dc.contributor.authorHershey, María Soledad
dc.contributor.authorO, Víctor de la
dc.contributor.authorFernández-Lázaro, César
dc.contributor.authorBes-Rastrollo, Maira
dc.contributor.authorMartín-Moreno, José M.
dc.contributor.authorSánchez Villegas, María Almudena
dc.contributor.authorMartínez Hernández, J. Alfredo
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2023-10-23T11:31:29Z
dc.date.available2023-10-23T11:31:29Z
dc.date.issued2023
dc.date.updated2023-10-23T10:54:13Z
dc.description.abstractObjectives: Novel findings indicate links between unhealthy lifestyles and depression based on active inflammatory processes. Thus, identifying participants with poor habits could reveal differences in trends of incident depression. This study aimed to examine the association between an objective lifestyle assessment, as measured by the Lifestyle and Well-Being Index (LWB-I), and incident depression in healthy participants of a Spanish cohort. Study design: This was a longitudinal analysis of a subsample of 10,063 participants from the Seguimiento Universidad de Navarra cohort study. Methods: Group comparisons and Cox proportional hazard models were conducted using the LWB-I, which categorizes the sample into groups with healthy and unhealthy lifestyles and well-being. The main outcome was incident depression as well as secondary outcomes. Results: Those classified to the transition category of LWB-I were associated with a hazard ratio of 0.67 (95% confidence interval: 0.52-0.87), and those in the excellent category showed a hazard ratio of 0.44 (95% confidence interval: 0.33-0.58), which in both groups reflects a significantly lower risk of incident depression compared with the group including those classified in the poor LWB-I level. Moreover, the available sensitivity analyses concerning time of depression diagnosis or antidepressant treatment further supported the role of nutrition and physical activity on incident depression. Interestingly, throughout the follow-up, incident depression was inversely related to healthier daily habits as measured by the LWB-I. Conclusions: A global assessment of lifestyles such as the LWB-I provides valuable insight into the complex relationship between lifestyle factors and their link to depression risk.en
dc.description.sponsorshipFunding was received from the Spanish Government-Instituto de Salud Carlos III , the European Regional Development Fund (FEDER; RD 06/0045, CIBER-OBN, grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI20/00564 and G03/140), the Navarra Regional Government (27/2011, 45/2011, 122/2014), the National Plan on Drugs (2020/021), and the University of Navarra.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPano, O., Sayón-Orea, C., Hershey, M. S., De La O, V., Fernández-Lázaro, C., Bes-Rastrollo, M., Martín-Moreno, J.-M., Sánchez-Villegas, A., & Martínez, J. A. (2023). The risk of incident depression when assessed with the Lifestyle and Well-Being Index. Public Health, 220, 165-171. https://doi.org/10.1016/j.puhe.2023.05.002en
dc.identifier.doi10.1016/j.puhe.2023.05.002
dc.identifier.issn0033-3506
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46626
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofPublic Health 220 (2023) 165-171en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI10/%2F02658/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI10/%2F02293/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F00615/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01668/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01798/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01764/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01795/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00564/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//27%2F2011/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//45%2F2011/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//122%2F2014/
dc.relation.publisherversionhttps://doi.org/10.1016/j.puhe.2023.05.002
dc.rights© 2023 The Author(s). This is an open access article under the CC BY-NC-ND license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDepressive disorderen
dc.subjectLifestyle habitsen
dc.subjectPrecision medicineen
dc.subjectUnipolar depressionen
dc.titleThe risk of incident depression when assessed with the lifestyle and well-being indexen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationae8afd07-1f10-4da5-8582-93b90a18aa88
relation.isAuthorOfPublication.latestForDiscoveryae8afd07-1f10-4da5-8582-93b90a18aa88

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