A multidimensional approach to assessing factors impacting health-related quality of life after pediatric traumatic brain injury

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dc.contributor.authorSteinbuechel, Nicole von
dc.contributor.authorKrenz, Ugne
dc.contributor.authorBockhop, Fabian
dc.contributor.authorKoerte, Inga
dc.contributor.authorTimmermann, Dagmar
dc.contributor.authorCunitz, Katrin
dc.contributor.authorZeldovich, Marina
dc.contributor.authorAndelic, Nada
dc.contributor.authorRojczyk, Philine
dc.contributor.authorBonfert, Michaela Veronika
dc.contributor.authorBerweck, Steffen
dc.contributor.authorKieslich, Matthias
dc.contributor.authorBrockmann, Knut
dc.contributor.authorRoediger, Maike
dc.contributor.authorLendt, Michael
dc.contributor.authorBuchheim, Anna
dc.contributor.authorMuehlan, Holger
dc.contributor.authorHolloway, Ivana
dc.contributor.authorOlabarrieta Landa, Laiene
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-10-17T07:41:30Z
dc.date.available2023-10-17T07:41:30Z
dc.date.issued2023
dc.date.updated2023-10-17T07:35:51Z
dc.description.abstractIn the field of pediatric traumatic brain injury (TBI), relationships between pre-injury and injury-related characteristics and post-TBI outcomes (functional recovery, post-concussion depression, anxiety) and their impact on disease-specific health-related quality of life (HRQoL) are under-investigated. Here, a multidimensional conceptual model was tested using a structural equation model (SEM). The final SEM evaluates the associations between these four latent variables. We retrospectively investigated 152 children (8–12 years) and 148 adolescents (13–17 years) after TBI at the recruiting clinics or online. The final SEM displayed a fair goodness-of-fit (SRMR = 0.09, RMSEA = 0.08 with 90% CI [0.068, 0.085], GFI = 0.87, CFI = 0.83), explaining 39% of the variance across the four latent variables and 45% of the variance in HRQoL in particular. The relationships between pre-injury and post-injury outcomes and between post-injury outcomes and TBI-specific HRQoL were moderately strong. Especially, pre-injury characteristics (children’s age, sensory, cognitive, or physical impairments, neurological and chronic diseases, and parental education) may aggravate post-injury outcomes, which in turn may influence TBI-specific HRQoL negatively. Thus, the SEM comprises potential risk factors for developing negative post-injury outcomes, impacting TBI-specific HRQoL. Our findings may assist healthcare providers and parents in the management, therapy, rehabilitation, and care of pediatric individuals after TBI.en
dc.description.sponsorshipThis research was funded by Dr. Senckenbergische Stiftung, Clementine Kinderhospital Dr. Christ‘sche Stiftungen (Germany), and Uniscientia Stiftung (Switzerland).en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationVon Steinbuechel, N., Krenz, U., Bockhop, F., Koerte, I. K., Timmermann, D., Cunitz, K., Zeldovich, M., Andelic, N., Rojczyk, P., Bonfert, M. V., Berweck, S., Kieslich, M., Brockmann, K., Roediger, M., Lendt, M., Buchheim, A., Muehlan, H., Holloway, I., & Olabarrieta-Landa, L. (2023). A multidimensional approach to assessing factors impacting health-related quality of life after pediatric traumatic brain injury. Journal of Clinical Medicine, 12(12), 3895. https://doi.org/10.3390/jcm12123895en
dc.identifier.doi10.3390/jcm12123895
dc.identifier.issn2077-0383
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46553
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofJournal of Clinical Medicine 2023, 12, 3895en
dc.relation.publisherversionhttps://doi.org/10.3390/jcm12123895
dc.rights© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdolescenten
dc.subjectAnxietyen
dc.subjectChilden
dc.subjectDepressionen
dc.subjectHealth-related quality of lifeen
dc.subjectPost-concussion symptomsen
dc.subjectTraumatic brain injuryen
dc.titleA multidimensional approach to assessing factors impacting health-related quality of life after pediatric traumatic brain injuryen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationf893b2b6-98c4-4fcc-b6e2-b80494f50a9c
relation.isAuthorOfPublication.latestForDiscoveryf893b2b6-98c4-4fcc-b6e2-b80494f50a9c

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