Additive effects of a family history of schizophrenia spectrum disorders and an environmental risk score for the outcome of patients with non-affective first-episode psychosis

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dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorGarcía de Jalón, Elena
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorGil Berrozpe, Gustavo José
dc.contributor.authorAranguren Conde, Lidia
dc.contributor.authorGutiérrez, Gerardo
dc.contributor.authorCorrales, Asier
dc.contributor.authorZarzuela, Amalia
dc.contributor.authorIbáñez Beroiz, Berta
dc.contributor.authorPeralta Martín, Víctor
dc.contributor.authorPEPsNa Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2024-09-09T10:41:05Z
dc.date.available2024-09-09T10:41:05Z
dc.date.issued2024
dc.date.updated2024-09-09T10:27:13Z
dc.description.abstractBackground: First-episode psychotic disorders comprise a heterogeneous phenotype with a complex etiology involving numerous common small-effect genetic variations and a wide range of environmental exposures. We examined whether a family of schizophrenia spectrum disorder (FH-Sz) interacts with an environmental risk score (ERS-Sz) regarding the outcome of patients with non-affective first episode psychosis (NAFEP). Methods: We included 288 patients with NAFEP who were evaluated after discharge from an intensive 2-year program. We evaluated three outcome measures: symptomatic remission, psychosocial functioning, and personal recovery. We analyzed the main and joint associations of a FH-Sz and the ERS-Sz on the outcomes by using the relative excess risk due to interaction (RERI) approach. Results: A FH-Sz showed a significant association with poor symptomatic remission and psychosocial functioning outcomes, although there was no significant interaction between a FH-Sz and the ERS-Sz on these outcomes. The ERS-Sz did not show a significant association with poor symptomatic remission and psychosocial functioning outcomes, even though the magnitude of the interaction between ERS-Sz and FH-Sz with the later outcome was moderate (RERI = 6.89, 95% confidence interval -16.03 to 29.81). There was no association between a FH-Sz and the ERS-Sz and personal recovery. Conclusions: Our results provide further empirical support regarding the contribution of FH-Sz to poor symptomatic remission and poor psychosocial functioning outcomes in patients with NAFEP.en
dc.description.sponsorshipThis work was supported by the Government of Navarra (grant 20/21) and by the Carlos III Health Institute (FEDER Funds) from the Spanish Ministry of Economy and Competitivity (16/2148 and 19/1698).
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.citationCuesta, M. J., De Jalón, E. G., Sánchez-Torres, A. M., Gil-Berrozpe, G. J., Aranguren, L., Gutierrez, G., Corrales, A., Zarzuela, A., Ibañez, B., Peralta, V., Group, Pep (2024) Additive effects of a family history of schizophrenia spectrum disorders and an environmental risk score for the outcome of patients with non-affective first-episode psychosis. Psychological Medicine, 1-9. https://doi.org/10.1017/S0033291724000576.
dc.identifier.doi10.1017/S0033291724000576
dc.identifier.issn0033-2917
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/51557
dc.language.isoeng
dc.publisherCambridge University Press
dc.relation.ispartofPsychological Medicine (2024)
dc.relation.publisherversionhttps://doi.org/10.1017/S0033291724000576
dc.rights© The Author(s), 2024.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectEnvironmental risk scoreen
dc.subjectFamily of schizophrenia spectrum disorderen
dc.subjectFirst-episode psychosisen
dc.subjectNon-affective psychosisen
dc.subjectRERIen
dc.titleAdditive effects of a family history of schizophrenia spectrum disorders and an environmental risk score for the outcome of patients with non-affective first-episode psychosisen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication377cf360-8d08-46f8-b10d-0785571f24c4
relation.isAuthorOfPublication6cc547dc-8ec5-4b66-b920-358328d1f12c
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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