Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls

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dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorRibeiro Fernández, María
dc.contributor.authorLópez-Ilundain, José M.
dc.contributor.authorLecumberri Villamediana, Pablo
dc.contributor.authorCabada Giadás, María Teresa
dc.contributor.authorLorente Omeñaca, Ruth
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorGómez Fernández, Marisol
dc.contributor.authorPeralta Martín, Víctor
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentMatemáticases_ES
dc.contributor.departmentMatematikaeu
dc.date.accessioned2024-01-30T19:36:02Z
dc.date.available2024-01-30T19:36:02Z
dc.date.issued2018
dc.date.updated2024-01-30T19:05:27Z
dc.description.abstractMotor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in psychosis remains understudied. This study aimed to examine comparatively the relationships between the whole range of motor abnormalities and cognitive impairments in the first-episode of psychosis (FEP), their unaffected siblings and healthy control subjects. Fifty FEP patients, 21 of their healthy siblings and 24 age- and sex matched healthy controls were included. Motor assessment included catatonic, extrapyramidal and neurological soft signs (NSS) by means of standardized instruments. An exhaustive neuropsychological battery was also performed to extract the 7 cognitive dimensions of MATRICS initiative. Higher scores on NSS but not on extrapyramidal and catatonic signs showed significant associations with worse cognitive performance in the three study groups. However, the pattern of associations regarding specific cognitive functions was different among the three groups. Moreover, extrapyramidal signs showed significant associations with cognitive impairment only in FEP patients but not in their unaffected siblings and healthy controls. Catatonic signs did not show any significant association with cognitive functioning in the three study groups. These findings add evidence to the associations between motor abnormalities, particularly NSS and extrapyramidal signs, and cognitive impairment in first-episode psychosis patients. In addition, our results suggest that the specific pattern of associations between MAs and cognitive functioning is different in FEP patients from those of the unaffected siblings and healthy subjects.en
dc.description.sponsorshipThis work was supported by the Department of Health of the Government of Navarra (grants 55/2007, 11/101 and 87/2014), the Carlos III Health Institute (FEDER Funds) from the Spanish Ministry of Economy and Competitivity (grant 11/02831) and the Spanish Ministry of Science and Innovation (grant SAF2008–05674-C03–02).en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.citationCuesta, M. J., Moreno-Izco, L., Ribeiro, M., López-Ilundain, J. M., Lecumberri, P., Cabada, T., Lorente-Omeñaca, R., Sánchez-Torres, A. M., Gómez, M. S., Peralta, V. (2018) Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls. Schizophrenia Research, 200, 50-55. https://doi.org/10.1016/j.schres.2017.10.035.en
dc.identifier.doi10.1016/j.schres.2017.10.035
dc.identifier.issn0920-9964
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/47263
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofSchizophrenia Research 200, (2018), 50–55en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PI11%2F02831/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//SAF2008-05674-C03-02/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra///
dc.relation.publisherversionhttps://doi.org/10.1016/j.schres.2017.10.035
dc.rights© 2017 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSchizophreniaen
dc.subjectFirst-episode psychosisen
dc.subjectUnaffected siblingsen
dc.subjectFirst-degree relativesen
dc.subjectHealthy controlsen
dc.subjectNeurological assessmenten
dc.subjectCatatoniaen
dc.subjectExtrapyramidal signsen
dc.subjectAkathisiaen
dc.subjectParkinsonismen
dc.subjectAbnormal movementsen
dc.subjectNeurological soft signsen
dc.subjectCognitive functioningen
dc.subjectCognitive impairmenten
dc.subjectMATRICSen
dc.titleMotor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controlsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
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