The effect of a multicomponent intervention on steatosis is partially mediated by the reduction of intermuscular abdominal adipose tissue in children with overweight or obesity: the EFIGRO Project

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dc.contributor.authorCadenas-Sánchez, Cristina
dc.contributor.authorIdoate, Fernando
dc.contributor.authorCabeza Laguna, Rafael
dc.contributor.authorVillanueva Larre, Arantxa
dc.contributor.authorRodríguez Vigil, Beatriz
dc.contributor.authorMedrano Echeverría, María
dc.contributor.authorOsés Recalde, Maddi
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentIngeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzareneu
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentIngeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2023-01-27T10:24:47Z
dc.date.available2023-01-27T10:24:47Z
dc.date.issued2022
dc.date.updated2023-01-26T13:20:01Z
dc.description.abstractOBJECTIVE: In adults, there is evidence that improvement of metabolic-associated fatty liver disease (MAFLD) depends on the reduction of myosteatosis. In children, in whom the prevalence of MAFLD is alarming, this muscle-liver crosstalk has not been tested. Therefore, we aimed to explore whether the effects of a multicomponent intervention on hepatic fat is mediated by changes in intermuscular abdominal adipose tissue (IMAAT) in children with overweight/obesity. RESEARCH DESIGN AND METHODS: A total of 116 children with overweight/obesity were allocated to a 22-week family-based lifestyle and psychoeducational intervention (control group, n = 57) or the same intervention plus supervised exercise (exercise group, n = 59). Hepatic fat percentage and IMAAT were acquired by MRI at baseline and at the end of the intervention. RESULTS: Changes in IMAAT explained 20.7% of the improvements in hepatic steatosis (P < 0.05). Only children who meaningfully reduced their IMAAT (i.e., responders) had improved hepatic steatosis at the end of the intervention (within-group analysis: responders -20% [P = 0.005] vs. nonresponders -1.5% [P = 0.803]). Between-group analysis showed greater reductions in favor of IMAAT responders compared with nonresponders (18.3% vs. 0.6%, P = 0.018), regardless of overall abdominal fat loss. CONCLUSIONS: The reduction of IMAAT plays a relevant role in the improvement of hepatic steatosis after a multicomponent intervention in children with overweight/obesity. Indeed, only children who achieved a meaningful reduction in IMAAT at the end of the intervention had a reduced percentage of hepatic fat independent of abdominal fat loss. Our findings suggest that abdominal muscle fat infiltration could be a therapeutic target for the treatment of MAFLD in childhood.en
dc.description.sponsorshipThis project was funded by the Spanish Ministry of Health's Fondos de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01335), the Spanish Ministry of the Economy Industry and Competitiveness (DEP2016-78377-R), and by European Regional Development Funds (ERDF): Una Manera de Hacer Europa. Support was also provided by the Regional Government of Navarra's Department of Economic Development (0011-1365-2019-000152 & 0011-1365-2020-000243), co-funded by European Regional Development Funds (ERDF 2014-2020 for Navarra). CC-S is supported by the Spanish Ministry of Science and Innovation (FJC2018-037925-I). MM is supported by Junta de Andalucía and European Union (SNGJ Ref-8025). MO is supported by the Spanish Ministry of Economy and Competitiveness (BES-2017-080770). This study was supported by the University of Granada Plan Propio de Investigación 2021 -Excellence actions: Unit of Excellence on Exercise, Nutrition and Health (UCEENS)- and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, European Regional Development Funds (ref. SOMM17/6107/UGR).en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCristina Cadenas-Sanchez, Fernando Idoate, Rafael Cabeza, Arantxa Villanueva, Beatriz Rodríguez-Vigil, María Medrano, Maddi Osés, Francisco B. Ortega, Jonatan R. Ruiz, Idoia Labayen; Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity: The EFIGRO Project. Diabetes Care 1 September 2022; 45 (9): 1953–1960. https://doi.org/10.2337/dc21-2440en
dc.identifier.doi10.2337/dc21-2440
dc.identifier.issn0149-5992
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/44618
dc.language.isoengen
dc.publisherAmerican Diabetes Associationen
dc.relation.ispartofDiabetes Care, 45(9), 1953-1960en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F01335/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2016-78377-R/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//FJC2018-037925-I/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//BES-2017-080770/
dc.relation.publisherversionhttps://doi.org/10.2337/dc21-2440
dc.rights© 2022 by the American Diabetes Associationen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectHepatic steatosisen
dc.subjectOverweight childrenen
dc.subjectObese childrenen
dc.subjectIntermuscular abdominal adipose tissue (IMAAT)en
dc.subjectMetabolic-associated fatty liver disease (MAFLD)en
dc.titleThe effect of a multicomponent intervention on steatosis is partially mediated by the reduction of intermuscular abdominal adipose tissue in children with overweight or obesity: the EFIGRO Projecten
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
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