Survival of frail elderly with delirium

Cano-Escalera, Guillermo; Graña, Manuel; Irazusta, Jon; Labayen Goñi, Idoia; Besga, Ariadna

Publication:
Survival of frail elderly with delirium

dc.contributor.author	Cano-Escalera, Guillermo
dc.contributor.author	Graña, Manuel
dc.contributor.author	Irazusta, Jon
dc.contributor.author	Labayen Goñi, Idoia
dc.contributor.author	Besga, Ariadna
dc.contributor.department	Institute on Innovation and Sustainable Development in Food Chain - ISFOOD	en
dc.date.accessioned	2022-04-12T10:44:01Z
dc.date.available	2022-04-12T10:44:01Z
dc.date.issued	2022
dc.description.abstract	This study aims to determine when frailty increases the risks of delirium mortality. Hospital patients falling into the elderly frail or pre-frail category were recruited, some without delirium, some with delirium at admission, and some who developed delirium during admission. We screened for frailty, cognitive status, and co-morbidities whenever possible and extracted drug information and mortality data from electronic health records. Kaplan–Meier estimates of survival probability functions were computed at four times, comparing delirium versus non delirium patients. Differences in survival were assessed by a log-rank test. Independent Cox’s regression was carried out to identify significant hazard risks (HR) at 1 month, 6 months, 1 year, and 2 years. Delirium predicted mortality (log-rank test, p < 0.0001) at all four censoring points. Variables with significant HRs were frailty indicators, comorbidities, polypharmacy, and the use of specific drugs. For the delirium cohort, variables with the most significant 2-year hazard risks (HR(95%CI)) were: male gender (0.43 20 (0.26,0.69)), weight loss (0.45 (0.26,0.74)), sit and stand up test (0.67 (0.49,0.92)), readmission within 30 days of discharge (0.50 (0.30,0.80)), cerebrovascular disease (0.45 (0.27,0.76)), head trauma (0.54 22 (0.29,0.98)), number of prescribed drugs (1.10 (1.03,1.18)), and the use of diuretics (0.57 (0.34,0.96)). These results suggest that polypharmacy and the use of diuretics increase mortality in frail elderly patients with delirium.	en
dc.description.sponsorship	The work in this paper was partially supported by FEDER funds for the MINECO project TIN2017-85827-P, and 2016111138 of the health funding program of the Basque Government. This project received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 777720.	en
dc.format.extent	18 p.
dc.format.mimetype	application/pdf	en
dc.identifier.doi	10.3390/ijerph19042247
dc.identifier.issn	1661-7827
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/42755
dc.language.iso	eng	en
dc.publisher	MDPI	en
dc.relation.ispartof	International Journal of Environmental Research and Public Health, 19 (4), 2022	en
dc.relation.projectID	info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/TIN2017-85827-P/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/777720	en
dc.relation.publisherversion	https://doi.org/10.3390/ijerph19042247
dc.rights	© 2022 by the authors. Creative Commons Attribution 4.0 International	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Ageing population	en
dc.subject	Delirium	en
dc.subject	Frailty	en
dc.subject	Hospital admission	en
dc.subject	Polypharmacy	en
dc.subject	Survival	en
dc.title	Survival of frail elderly with delirium	en
dc.type	info:eu-repo/semantics/article
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dspace.entity.type	Publication
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relation.isAuthorOfPublication.latestForDiscovery	b36e2b1d-3088-4089-806e-fd3040e9583a