Effect of black garlic consumption on endothelial function and lipid profile: a before-and-after study in hypercholesterolemic and non-hypercholesterolemic subjects
| dc.contributor.author | Villaño Valencia, Débora | |
| dc.contributor.author | Marhuenda, Javier | |
| dc.contributor.author | Arcusa, Raúl | |
| dc.contributor.author | Moreno-Rojas, José Manuel | |
| dc.contributor.author | Cerdá, Begoña | |
| dc.contributor.author | Pereira-Caro, Gema | |
| dc.contributor.author | Zafrilla, Pilar | |
| dc.contributor.department | Agronomía, Biotecnología y Alimentación | es_ES |
| dc.contributor.department | Agronomia, Bioteknologia eta Elikadura | eu |
| dc.contributor.department | Institute on Innovation and Sustainable Development in Food Chain - ISFOOD | en |
| dc.date.accessioned | 2023-10-30T19:44:00Z | |
| dc.date.available | 2023-10-30T19:44:00Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2023-10-30T19:27:54Z | |
| dc.description.abstract | Background: Black garlic is obtained from raw garlic (Allium sativum L.), by a fermentation process, under humidity and heat treatment, showing a high concentration of organosulfur compounds, which have been related to benefits in the prevention or delay of cardiovascular diseases (CVDs). The objective of the research was to evaluate whether long-term consumption of black garlic improves endothelial function and lipid profile in subjects with hypercholesterolemia. Methods: Single center, controlled clinical trial with two branches: Hypercholesterolemia vs. Healthy condition. Sixty-two subjects of both sexes were distributed in two groups, the hypercholesterolemia group (n = 31) (total cholesterol (TC) range 200-300 mg/dL and low-density lipoprotein (LDL)-cholesterol range 135-175 mg/dL) and the healthy group (n = 31). The intervention consisted of the ingestion of 4 cloves of black garlic (12 g) daily for 12 weeks. Results: significant increases in Apolipoprotein (Apo)A1 occurred in both groups: Hypercholesterolemia (& UDelta; 11.8 mg/dL p < 0.001) vs Healthy (& UDelta; 11.1 mg/dL p < 0.001). Besides, significant reductions for endothelial adhesion molecules monocyte chemoattractant protein-1 (MCP-1) (& UDelta; -121.5 pg/mL p = 0.007 vs. & UDelta; -56.3 pg/mL p = 0.015), intracellular adhesion molecule-1 (ICAM-1) (& UDelta; -39.3 ng/mL p < 0.001 vs. & UDelta; 63.5 ng/mL p < 0.001), and vascular cyto-adhesion molecule-1 (VCAM-1) (& UDelta; -144.4 ng/mL p < 0.001 vs. & UDelta; -83.4 ng/mL p = 0.061) were observed, for hypercholesterolemic and healthy subjects, respectively. Conclusions: These data show that black garlic consumption could improve some parameters related to endothelial function and lipid profile, which may have a favorable impact on the risk of CVDs, although more long-term studies are necessary to confirm. | en |
| dc.description.sponsorship | This research was funded by the Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA) and the European Rural Development Fund (ERDF, EU) through the Project Caracterizacion, biodisponibilidad y potencial saludable de compuestos bioactivos de alimentos PP.AVA.AVA2019.037. G.P.-C. was supported by a postdoctoral research contract Programa Emergia 2020 funded by the Secretaria General de Universidades, Investigacion e Innovacion, Junta de Andalucia. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Villaño, D., Marhuenda, J., Arcusa, R., Moreno-Rojas, J. M., Cerdá, B., Pereira-Caro, G., Zafrilla, P. (2023) Effect of black garlic consumption on endothelial function and lipid profile: a before-and-after study in hypercholesterolemic and non-hypercholesterolemic subjects. Nutrients, 15(14), 1-13. https://doi.org/10.3390/nu15143138. | en |
| dc.identifier.doi | 10.3390/nu15143138 | |
| dc.identifier.issn | 2072-6643 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/46689 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Nutrients 2023, 15(14), 3138 | en |
| dc.relation.publisherversion | https://doi.org/10.3390/nu15143138 | |
| dc.rights | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Cardiometabolic diseases (CMDs) | en |
| dc.subject | Nutrition strategies | en |
| dc.subject | Black garlic | en |
| dc.subject | Organosulfur compounds | en |
| dc.subject | Endothelial adhesion molecules | en |
| dc.title | Effect of black garlic consumption on endothelial function and lipid profile: a before-and-after study in hypercholesterolemic and non-hypercholesterolemic subjects | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | adfd76fd-4a8f-4510-991e-d614a266211d | |
| relation.isAuthorOfPublication.latestForDiscovery | adfd76fd-4a8f-4510-991e-d614a266211d |