Dairy product consumption and changes in cognitive performance: two-year analysis of the PREDIMED-Plus Cohort
dc.contributor.author | Ni, Jiaqi | |
dc.contributor.author | Nishi, Stephanie K. | |
dc.contributor.author | Babio, Nancy | |
dc.contributor.author | Martínez González, Miguel Ángel | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Castañer, Olga | |
dc.contributor.author | Martínez, Jose Alfredo | |
dc.contributor.author | Alonso Gómez, Ángel M. | |
dc.contributor.author | Gómez-Gracia, Enrique | |
dc.contributor.author | Vioque, Jesús | |
dc.contributor.author | Romaguera, Dora | |
dc.contributor.author | López Miranda, José | |
dc.contributor.author | Estruch, Ramón | |
dc.contributor.author | Tinahones, Francisco J. | |
dc.contributor.author | Lapetra, José | |
dc.contributor.author | Serra-Majem, Lluis | |
dc.contributor.author | Bueno Cavanillas, Aurora | |
dc.contributor.author | Tur, Josep A. | |
dc.contributor.author | Martín-Sánchez, Vicente | |
dc.contributor.author | Pintó, Xavier | |
dc.contributor.author | Gaforio, José J. | |
dc.contributor.author | Barabash Bustelo, Ana | |
dc.contributor.author | Vidal, Josep | |
dc.contributor.author | Vázquez, Clotilde | |
dc.contributor.author | Daimiel, Lidia | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Toledo, Estefanía | |
dc.contributor.author | Coltell, Oscar | |
dc.contributor.author | Gómez-Martínez, Carlos | |
dc.contributor.author | Zomeño, María Dolores | |
dc.contributor.author | Donat Vargas, Carolina | |
dc.contributor.author | Goicolea-Güemez, Leire | |
dc.contributor.author | Bouzas, Cristina | |
dc.contributor.author | García de la Hera, Manuela | |
dc.contributor.author | Chaplin, Alice | |
dc.contributor.author | García-Rios, Antonio | |
dc.contributor.author | Casas, Rosa | |
dc.contributor.author | Cornejo-Pareja, Isabel | |
dc.contributor.author | Santos Lozano, José Manuel | |
dc.contributor.author | Rognoni, Teresa | |
dc.contributor.author | Saiz, Carmen | |
dc.contributor.author | Paz-Graniel, Indira | |
dc.contributor.author | Malcampo, Mireia | |
dc.contributor.author | Sánchez Villegas, María Almudena | |
dc.contributor.author | Salaverria-Lete, Itziar | |
dc.contributor.author | García-Arellano, Ana | |
dc.contributor.author | Schröder, Helmut | |
dc.contributor.author | Salas-Salvadó, Jordi | |
dc.contributor.department | Institute on Innovation and Sustainable Development in Food Chain - ISFOOD | en |
dc.date.accessioned | 2023-02-06T07:37:06Z | |
dc.date.available | 2023-02-06T07:37:06Z | |
dc.date.issued | 2022 | |
dc.date.updated | 2023-01-16T07:37:16Z | |
dc.description.abstract | Scope: Dairy consumption has been suggested to impact cognition; however, evidence is limited and inconsistent. This study aims to longitudinally assess the association between dairy consumption with cognitive changes in an older Spanish population at high cardiovascular disease risk. Methods and results: Four thousand six hundred sixty eight participants aged 55–75 years, completed a validated food frequency questionnaire at baseline and a neuropsychological battery of tests at baseline and 2-year follow-up. Multivariable linear regression models are used, scaled by 100 (i.e., the units of β correspond to 1 SD/100), to assess associations between baseline tertile daily consumption and 2-year changes in cognitive performance. Participants in the highest tertile of total milk and whole-fat milk consumption have a greater decline in global cognitive function (β: –4.71, 95% CI: –8.74 to –0.69, p-trend = 0.020 and β: –6.64, 95% CI: –10.81 to –2.47, p-trend = 0.002, respectively) compared to those in the lowest tertile. No associations are observed between low fat milk, yogurt, cheese or fermented dairy consumption, and changes in cognitive performance. Conclusion:Results suggest there are no clear prospective associations between consumption of most commonly consumed dairy products and cognition, although there may be an association with a greater rate of cognitive decline over a 2-year period in older adults at high cardiovascular disease risk for whole-fat milk. | en |
dc.description.sponsorship | This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is cofunded by the European Regional Development Fund (six coordinated FIS projects leaded by J.S.-S. and J.Vi., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/ 02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/ 01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/ 00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/ 01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/ 00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to JS-S.; the European Research Council (Advanced Research Grant 2014– 2019; agreement #340918) granted to MÁM-G.; the Recercaixa (number 2013ACUP00194) grant to JS-S.; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 and PROMETEO/2021/021 grants from the Generalitat Valenciana; the SEMERGEN grant; Juan de la Cierva–Incorporación research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds to JK. This research was also partially funded by EU-H2020 Grants (Eat2beNICE/ H2020-SFS-2016-2; and the Horizon 2020 PRIME study (Prevention and Remediation of Insulin Multimorbidity in Europe; grant agreement #847879). J.N. is supported by a predoctoral grant from Ministerio de Ciencia, Innovación y Universidades (FPU 20/00385). SKN is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR). C.G.-M. is supported by a predoctoral grant from the University of Rovira I Virgili (2020PMF-PIPF-37). I.P.-G. is supported by a predoctoral grant from Ministerio de Ciencia, Innovación y Universidades (FPU 17/01925). J.S.-S., senior author of this paper, was partially supported by ICREA under the ICREA Academia program. | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Ni, J., Nishi, S. K., Babio, N., Martínez‐González, M. A., Corella, D., Castañer, O., Martínez, J. A., Alonso‐Gómez, Á. M., Gómez‐Gracia, E., Vioque, J., Romaguera, D., López‐Miranda, J., Estruch, R., Tinahones, F. J., Lapetra, J., Serra‐Majem, J. L., Bueno‐Cavanillas, A., Tur, J. A., Martín‐Sánchez, V., … PREDIMED‐Plus investigators. (2022). Dairy product consumption and changes in cognitive performance: Two‐year analysis of the predimed‐plus cohort. Molecular Nutrition & Food Research, 66(14), 2101058. https://doi.org/10.1002/mnfr.202101058 | en |
dc.identifier.doi | 10.1002/mnfr.202101058 | |
dc.identifier.issn | 1613-4125 | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/44658 | |
dc.language.iso | eng | en |
dc.publisher | Wiley | en |
dc.relation.ispartof | Molecular Nutrition and Food Research 2022, 66, 2101058 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F00673/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F00492/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F00272/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F01123/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F00462/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F00233/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F02184/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F00728/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F01090/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F01056/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01722/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F00636/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F00618/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F00696/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01206/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01919/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F00853/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01374/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F00972/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F00728/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01471/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F00473/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F00662/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F01873/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F01094/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F00501/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F00533/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F00381/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F00366/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F01522/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F01120/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F00764/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01183/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F00855/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01347/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F00525/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01827/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F00532/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F00215/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01441/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F00508/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01732/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F00926/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F00957/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F00386/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F00309/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F01032/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F00576/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F00017/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F01226/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F00781/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F01560/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI19%2F01332/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F01802/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00138/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F01532/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00456/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00339/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00557/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00886/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F01158/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/IJC2019-042420-I/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/728018/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/847879/ | |
dc.relation.projectID | info:eu-repo/grantAgreement///FPU 20%2F00385/ | |
dc.relation.projectID | info:eu-repo/grantAgreement///FPU 17%2F01925/ | |
dc.relation.publisherversion | https://doi.org/10.1002/mnfr.202101058 | |
dc.rights | © 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purpose | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | Cognition | en |
dc.subject | Cognitive decline | en |
dc.subject | Dairy | en |
dc.subject | Milk | en |
dc.subject | PREDIMED-Plus | en |
dc.title | Dairy product consumption and changes in cognitive performance: two-year analysis of the PREDIMED-Plus Cohort | en |
dc.type | info:eu-repo/semantics/article | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | ae8afd07-1f10-4da5-8582-93b90a18aa88 | |
relation.isAuthorOfPublication.latestForDiscovery | ae8afd07-1f10-4da5-8582-93b90a18aa88 |