Early epigenetic changes of Alzheimer's disease in the human hippocampus

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dc.contributor.authorBlanco Luquin, Idoia
dc.contributor.authorAcha Santamaría, Blanca
dc.contributor.authorUrdánoz Casado, Amaya
dc.contributor.authorSánchez Ruiz de Gordoa, Javier
dc.contributor.authorVicuña-Urriza, Janire
dc.contributor.authorRoldán, Miren
dc.contributor.authorLabarga Gutiérrez, Alberto
dc.contributor.authorZelaya Huerta, María Victoria
dc.contributor.authorCabello, Carolina
dc.contributor.authorMéndez López, Iván
dc.contributor.authorMendióroz Iriarte, Maite
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentSociología y Trabajo Sociales_ES
dc.contributor.departmentSoziologia eta Gizarte Lanaeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2024-08-02T08:17:12Z
dc.date.available2024-08-02T08:17:12Z
dc.date.issued2020
dc.date.updated2024-08-02T07:46:23Z
dc.description.abstractThe discovery of new biomarkers would be very valuable to improve the detection of early Alzheimer's disease (AD). DNA methylation marks may serve as epigenetic biomarkers of early AD. Here we identified epigenetic marks that are present in the human hippocampus from the earliest stages of AD. A previous methylome dataset of the human AD hippocampus was used to select a set of eight differentially methylated positions (DMPs) since early AD stages. Next, bisulphite pyrosequencing was performed in an expanded homogeneous cohort of 18 pure controls and 35 hippocampal samples with neuropathological changes of pure AD. Correlation between DNA methylation levels in DMPs and phospho-tau protein burden assessed by immunohistochemistry in the hippocampus was also determined. We found four DMPs showing higher levels of DNA methylation at early AD stages compared to controls, involving ELOVL2, GIT1/TP53I13 and the histone gene locus at chromosome 6. DNA methylation levels assessed by bisulphite pyrosequencing correlated with phospho-tau protein burden for ELOVL2 and HIST1H3E/HIST1H3 F genes. In this discovery study, a set of four epigenetic marks of early AD stages have been identified in the human hippocampus. It would be worth studying in-depth the specific pathways related to these epigenetic marks. These early alterations in DNA methylation in the AD hippocampus could be regarded as candidate biomarkers to be explored in future translational studies.en
dc.description.sponsorshipThis work was supported by the European Regional Development Fund; Instituto de Salud Carlos III [FIS PI13/02730 and PI17/02218]; 'la Caixa' Foundation (ES); PRECIPITA platform (Spanish foundation for science and technology-FECYT); Fundación Caja-Navarra; The Basque Foundation for Health Innovation and Research [BIO12/ALZ/007]; Trans-Pyrenean Biomedical Research Network (REFBIOI and REFBIOII); Spanish Government [PFIS fellowship FI18/00150]; Government of Navarra [Doctorados industriales 2018-2020]; 'la Caixa' Foundation and Fundación Caja-Navarra [Programa de intensificación].
dc.format.extentP. 1083–1092
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBlanco-Luquin, I., Acha, B., Urdánoz-Casado, A., Sánchez-Ruiz De Gordoa, J., Vicuña-Urriza, J., Roldán, M., Labarga, A., Zelaya, M.V., Cabello, C., Méndez-López, I., Mendioroz, M. (2020) Early epigenetic changes of Alzheimer's disease in the human hippocampus. Epigenetics. https://doi.org/10.1080/15592294.2020.1748917.
dc.identifier.doi10.1080/15592294.2020.1748917
dc.identifier.issn1559-2294
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/50603
dc.language.isoeng
dc.relation.ispartofEpigenetics (2020), vol. 15, núm. 10
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F02730/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F02218/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//FI18%2F00150/
dc.relation.publisherversionhttps://doi.org/10.1080/15592294.2020.1748917
dc.rights© 2020 Informa UK Limited, trading as Taylor & Francis Group.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectEarly Alzheimer's diseaseen
dc.subjectHippocampusen
dc.subjectEpigeneticsen
dc.subjectBiomarkersen
dc.subjectDNA methylationen
dc.subjectELOVL2en
dc.subjectGIT1en
dc.subjectHistoneen
dc.subjectFatty aciden
dc.titleEarly epigenetic changes of Alzheimer's disease in the human hippocampusen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
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