Quality of life in Spanish advanced non-small-cell lung cancer patients: determinants of global QL and survival analyses
Fecha
2016Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.1186/s40064-016-2559-9
Resumen
Purpose: This paper studies the Quality of Life (QL) of Spanish advanced non-small-cell lung cancer (NSCLC) patients
receiving platinum-doublet chemotherapy, compares our results with those from studies from other cultural areas,
and identifies factors associated with global QL and survival prognostic variables.
Methods: EORTC QLQ-C30 and QLQ-LC13 questionnaires were completed three times by 3 ...
[++]
Purpose: This paper studies the Quality of Life (QL) of Spanish advanced non-small-cell lung cancer (NSCLC) patients
receiving platinum-doublet chemotherapy, compares our results with those from studies from other cultural areas,
and identifies factors associated with global QL and survival prognostic variables.
Methods: EORTC QLQ-C30 and QLQ-LC13 questionnaires were completed three times by 39 patients along treatment
and follow-up. Univariate and multivariate logistic regression analyses were performed to study global QL determinants
(≤50 points considered low global-QL score). Analyses of prognostic variables for death were performed
(Cox proportional hazards models).
Results: QL mean scores in the whole sample were moderately high, with limitations (>30) in physical, role, social
functioning, emotional areas, fatigue, pain, neuropathy and global QL. Differences with studies from other cultural
areas were mainly found in the lower score for dyspnoea (≥15 points). There were no significant differences in QL
scores between the first and second assessments. In six areas, the third assessment was lower than the first and
second: fatigue, hair loss (>20 points); physical, social functioning, neuropathy (10–20 points); emotional functioning
(5–10 points). The best model to explain the chances of low QL includes, as explanatory variables, high emotional
functioning as protective factor and fatigue as risk factor (R2 = 0.70). Eight QL areas (four pain-related) and performance
status showed a statistically significant association with survival.
Conclusion: Patients adapted well to their disease and treatments. Platinum-doublet can be administered in
advanced NSCLC patients. Our QL data are in line with those from other cultural areas. [--]
Materias
Advanced lung cancer,
Quality of life,
Survival,
Determinants
Editor
Springer
Publicado en
SpringerPlus (2016) 5:836
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
This study was supported by grants from the Instituto de Salud Carlos III
and the Departamento de Salud del Gobierno de Navarra, Spain, to finance
a research assistant to interview the patients.
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