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PD1 signal transduction pathways in T cells
The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating ... -
PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity
PDL1 blockade produces remarkable clinical responses, thought to occur by T cell reactivation through prevention of PDL1-PD1 T cell inhibitory interactions. Here, we find that PDL1 cell-intrinsic signaling protects cancer ... -
Pediatric version of the nurse caring behavior scale: a cross-sectional study in pediatric hemato-oncology centers
Background and purpose: Caring is an essential value in nursing, it's crucial in pediatric hemato-oncology: we tested the Nurse Caring Behavior Scale (NCBS) in this setting. Methods: The NCBS is a 14-item validated ... -
Pediococcus acidilactici pA1c® improves the beneficial effects of metformin treatment in type 2 diabetes by controlling glycaemia and modulating intestinal microbiota
Type 2 diabetes (T2D) is a complex metabolic disease, which involves maintained hyperglycemia, mainly due to the development of an insulin resistance process. Metformin administration is the most prescribed treatment for ... -
Perceived neighborhood environmental attributes associated with walking and cycling for transport among adult residents of 17 cities in 12 countries: the IPEN study
Introduction: Prevalence of walking and cycling for transport is low and varies greatly across countries. Few studies have examined neighborhood perceptions related to walking and cycling for transport in different countries. ... -
Perceived neighbourhood environmental attributes associated with adults’ recreational walking: IPEN Adult study in 12 countries
This study examined the strength and shape of associations between perceived environmental attributes and adults’ recreational walking, using data collected from 13,745 adult participants in 12 countries. Perceived residential ... -
Percepción de cuidadoras inmigrantes extranjeras. Sobre el cuidado, genérico y profesional enfermero, al anciano en domicilio
En la presente investigación, se aborda el tema de los cuidadores/as inmigrantes extranjeros en asistencia a domicilio a personas ancianas y/o dependientes, con objeto de determinar su preparación, necesidades, integración, ... -
Percepción de factores psicosociales y del entorno relacionados con el desplazamiento activo
El desplazamiento activo, bien caminando o en bicicleta, contribuye a incrementar el nivel de actividad física de las personas. Este hábito podría favorecerse actuando sobre ciertos factores psicosociales, y creando entornos ... -
The perception and management of emotions in nursing students under clinical training
(Escuela de Enfermería, Facultad de Medicina, Pontificia Universidad Católica de Chile, 2022) Artículo / ArtikuluaBACKGROUND: Patient care must be understood holistically and to achieve this goal, nurses must be aware and familiar with the world of emotions. Poor handling of emotions by nursing professionals can affect their health, ... -
Perfil de la demanda urgente e influencia del fútbol televisado en un servicio extrahospitalario en la Zona Básica de Salud de Tafalla, Navarra
Fundamento: la demanda a los servicios de urgencias, tanto hospitalarios como extrahospitalarios, mantiene un ritmo creciente. El objetivo del presente trabajo es doble: cuantificación y estudio de las características ... -
Performance of fuzzy multi-criteria decision analysis of emergency system in COVID-19 pandemic. An extensive narrative review
The actual coronavirus disease 2019 (COVID-19) pandemic has led to the limit of emergency systems worldwide, leading to the collapse of health systems, police, first responders, as well as other areas. Various ways of ... -
Periostin plasma levels and changes on physical and cognitive capacities in community-dwelling older adults
Periostin, involved in extracellular matrix development and support, has been shown to be elevated in senescent tissues and fibrotic states, transversal signatures of aging. We aimed to explore associations between plasma ... -
Personal and perceived peer use and attitudes towards the use of nonmedical prescription stimulants to improve academic performance among university students in seven European countries
Background: Overestimations of non-prescribed stimulant use of peers are well documented in the USA and have also been identified as predictive of personal stimulant consumption. This study aimed to examine whether ... -
Personal and perceived peer use and attitudes towards use of non-prescribed prescription sedatives and sleeping pills among university students in seven European countries
Introduction: The use of non-prescribed prescription sedatives and sleeping pills (NPPSSP) among university students has been described as an important public health issue. However, the impact of perceived social norms on ... -
La pesca industrial y la emigración gallega en Trintxerpe, 1920-1970
La técnica de pesca del arrastre y la máquina de vapor, supone el desarrollo de la pesca industrial a inicios del siglo XX. Esta presentación estudia los movimientos demográficos de marineros gallegos y de mujeres, hacia ... -
Pesca industrial: patrimonio inmaterial e historia oral. Imaginarios del pasado s. XX
El patrimonio inmaterial y la historia oral, así como las actitudes metodológicas en torno a la recogida de la información, nos muestran la interpretación en torno a la pesca, sus mundos, saberes y sostenibilidad, desde ... -
Phonological and semantic verbal fluency test: Scoring criteria and normative data for clustering and switching strategies for Colombian children and adolescents
Background: Verbal fluency tests (VFT) are highly sensitive to cognitive deficits. Usually, the score on VFT is based on the number of correct words produced, yet it alone gives little information regarding underlying test ... -
Physical activity guidelines for older people: knowledge gaps and future directions
Physical function (ie, aerobic capacity, gait speed, and muscle strength) has been proposed as a biomarker of healthy ageing, as it is predictive of adverse health events, disability, and mortality. The role of physical ... -
Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging
Background: Physical activity (PA) is a recognized contributor to healthy aging. However, the majority of studies exploring its associations with adverse outcomes in cohorts of older adults use single-time PA estimates, ... -
Physical activity, sedentary behavior, sleep and self-regulation in Spanish preschoolers during the COVID-19 lockdown
Background: A better understanding of the effects of the lockdown on lifestyle behaviors may help to guide the public health response to COVID-19 at a national level and to update the global strategy to respond COVID-19 ...