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Functional analysis of intergenic regulatory regions of genes encoding surface adhesins in Staphylococcus aureus isolates from periprosthetic joint infections
(Elsevier, 2022)
Artículo / Artikulua,
Staphylococcus aureus is a leading cause of prosthetic joint infections (PJI). Surface adhesins play an important
role in the primary attachment to plasma proteins that coat the surface of prosthetic devices after ...
RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria
(Oxford University Press, 2011)
Artículo / Artikulua,
Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ...
Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
(Nature Research, 2020)
Artículo / Artikulua,
Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the
aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS)
that determines bacterial ...
Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus
(Public Library of Science, 2013)
Artículo / Artikulua,
The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability
and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ...
Staphylococcus aureus develops an alternative, ica-independent biofilm in the absence of the arlRS two-component system
(American Society for Microbiology, 2005)
info:eu-repo/semantics/article,
The biofilm formation capacity of Staphylococcus aureus clinical isolates is considered an important virulence
factor for the establishment of chronic infections. Environmental conditions affect the biofilm formation
capacity ...
SarA positively controls Bap-dependent biofilm formation in Staphylococcus aureus
(American Society for Microbiology, 2005)
info:eu-repo/semantics/article,
The biofilm-associated protein Bap is a staphylococcal surface protein involved in biofilm formation. We
investigated the influence of the global regulatory locus sarA on bap expression and Bap-dependent biofilm
formation ...
Sensory deprivation in Staphylococcus aureus
(Springer Nature, 2018)
info:eu-repo/semantics/article,
Bacteria use two-component systems (TCSs) to sense and respond to environmental
changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16
TCSs, one of which (WalRK) is essential. Here we show ...
Killing niche competitors by remote-control bacteriophage induction
(National Academy of Sciences, 2009)
info:eu-repo/semantics/article,
A surprising example of interspecies competition is the production
by certain bacteria of hydrogen peroxide at concentrations that are
lethal for others. A case in point is the displacement of Staphylococcus
aureus by ...
Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
(American Society for Microbiology, 2006)
info:eu-repo/semantics/article,
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus
aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer ...
The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus
(Oxford University Press, 2018)
info:eu-repo/semantics/article,
RNA-binding proteins (RBPs) are essential to finetune
gene expression. RBPs containing the coldshock
domain are RNA chaperones that have been
extensively studied. However, the RNA targets and
specific functions for ...