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dc.creatorAgostinis-Sobrinho, Césares_ES
dc.creatorGómez-Martínez, Soniaes_ES
dc.creatorNova, Estheres_ES
dc.creatorHernández, Auroraes_ES
dc.creatorLabayen Goñi, Idoiaes_ES
dc.creatorKafatos, Antonioses_ES
dc.creatorGottand, Frederices_ES
dc.creatorMolnár, Déneses_ES
dc.creatorFerrari, Marikaes_ES
dc.creatorMoreno, Luis A.es_ES
dc.description.abstractObjective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents. Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors, and sleep duration. We also measured endocrine, metabolic, and immunological biomarkers. Results: Three-cluster solutions were identified: (a) light-PA time, moderate-vigorous-PA time and sedentary time, (b) light-PA time, moderate-vigorous-PA time, sedentary time and sleep time, (c) light-PA time, moderate-vigorous-PA time, sedentary time and body composition. In addition, each cluster solution was defined as: “healthy,” “medium healthy,” and “unhealthy” according to the presented rating. Analysis of variance showed that overall the healthiest groups from the three clusters analyzed presented a better metabolic profile. A decision tree analysis showed that leptin had a strong association with cluster 3 in both boys and girls, high-density lipoprotein cholesterol had the strongest association with clusters 1 and 3 in boys. Cortisol had the strongest association with cluster 1. HOMA index (homeostatic model assessment) and C3 showed a strong association with cluster 3 in girls. Conclusions: Our results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness, and sleep, with some gender-specific findings. These results highlight the importance to consider multiple lifestyle-related health factors in the assessment of adolescents' health to plan favorable strategies.en
dc.description.sponsorshipThe HELENA Study was carried out with the financial support of the European Community Sixth RTD Framework Programme (Contract FOODCT-2005-007034). The study was partially supported by the Redes temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), and by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES).en
dc.format.extent29 p.
dc.relation.ispartofPediatric Diabetes, 2019; 20: 23 –31en
dc.rights© 2018 John Wiley & Sons A/Sen
dc.subjectCardiometabolic biomarkersen
dc.subjectPhysical activityen
dc.subjectSedentary behavioren
dc.subjectSleep timeen
dc.titleLifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA studyen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.type.versionVersión aceptada / Onetsi den bertsioaes

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