Development of a genetic risk score to predict the risk of hypertension in european adolescents from the HELENA study
Fecha
2023Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
Impacto
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10.3389/fcvm.2023.1118919
Resumen
Introduction: From genome wide association study (GWAS) a large number of single nucleotide polymorphisms (SNPs) have previously been associated with blood pressure (BP) levels. A combination of SNPs, forming a genetic risk score (GRS) could be considered as a useful genetic tool to identify individuals at risk of developing hypertension from early stages in life. Therefore, the aim of our study ...
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Introduction: From genome wide association study (GWAS) a large number of single nucleotide polymorphisms (SNPs) have previously been associated with blood pressure (BP) levels. A combination of SNPs, forming a genetic risk score (GRS) could be considered as a useful genetic tool to identify individuals at risk of developing hypertension from early stages in life. Therefore, the aim of our study was to build a GRS being able to predict the genetic predisposition to hypertension (HTN) in European adolescents.
Methods: Data were extracted from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. A total of 869 adolescents (53% female), aged 12.5–17.5, with complete genetic and BP information were included. The sample was divided into altered (≥130 mmHg for systolic and/or ≥80 mmHg for diastolic) or normal BP. Based on the literature, a total of 1.534 SNPs from 57 candidate genes related with BP were selected from the HELENA GWAS database.
Results: From 1,534 SNPs available, An initial screening of SNPs univariately associated with HTN (p < 0.10) was established, to finally obtain a number of 16 SNPs significantly associated with HTN (p < 0.05) in the multivariate model. The unweighted GRS (uGRS) and weighted GRS (wGRS) were estimated. To validate the GRSs, the area under the curve (AUC) was explored using ten-fold internal cross-validation for uGRS (0.802) and wGRS (0.777). Further covariates of interest were added to the analyses, obtaining a higher predictive ability (AUC values of uGRS: 0.879; wGRS: 0.881 for BMI z-score). Furthermore, the differences between AUCs obtained with and without the addition of covariates were statistically significant (p < 0.05).
Conclusions: Both GRSs, the uGRS and wGRS, could be useful to evaluate the predisposition to hypertension in European adolescents. [--]
Materias
Adolescents,
Blood pressure,
Europe,
Genetic risk score,
Hypertension,
Prevention
Editor
Frontiers Media
Publicado en
Frontiers in Cardiovascular Medicine 2023, 10: 1118919
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila /
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Versión del editor
Entidades Financiadoras
The HELENA Study was financial support of the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034). GP-G, has receiving a predoctoral fellowship from the Government of Aragón. DFS-T was supported by a Marie S. Curie Global Fellowship within the European Union research and innovation framework programme (2014–2020; ClimAHealth: 101030971). MS-C has received funding from the Iberus Talent Pre-doctoral fellowships 2018, under the European Union's H2020 research and innovation programme under Marie Sklodowska-Curie grant agreement No. 801586. This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project “PI20/00988” and co-funded by the European Union.
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La licencia del ítem se describe como © 2023 Pérez-Gimeno, Seral-Cortes,
Sabroso-Lasa, Esteban, Lurbe, Béghin,
Gottrand, Meirhaeghe, Muntaner, Kafatos,
Molnár, Leclercq, Widhalm, Kersting, Nova,
Salazar-Tortosa, Gonzalez-Gross, Breidenassel,
Sinningen, De Ruyter, Labayen, Rupérez,
Bueno-Lozano and Moreno. This is an openaccess
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Creative Commons Attribution License (CC BY).