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Development of a genetic risk score to predict the risk of hypertension in european adolescents from the HELENA study
dc.creator | Pérez-Gimeno, Gloria | es_ES |
dc.creator | Seral-Cortes, Miguel | es_ES |
dc.creator | Sabroso-Lasa, Sergio | es_ES |
dc.creator | Esteban, Luis Mariano | es_ES |
dc.creator | Lurbe, Empar | es_ES |
dc.creator | Béghin, Laurent | es_ES |
dc.creator | Gottrand, Frédéric | es_ES |
dc.creator | Meirhaeghe, Aline | es_ES |
dc.creator | Muntaner, Manon | es_ES |
dc.creator | Kafatos, Antonios | es_ES |
dc.creator | Molnár, Dénes | es_ES |
dc.creator | Leclercq, Catherine | es_ES |
dc.creator | Widhalm, Kurt | es_ES |
dc.creator | Kersting, Mathilde | es_ES |
dc.creator | Nova, Esther | es_ES |
dc.creator | Salazar-Tortosa, Diego | es_ES |
dc.creator | González Gross, Marcela | es_ES |
dc.creator | Breidenassel, Christina | es_ES |
dc.creator | Sinningen, Kathrin | es_ES |
dc.creator | Ruyter, Thaïs de | es_ES |
dc.creator | Labayen Goñi, Idoia | es_ES |
dc.creator | Rupérez, Azahara I. | es_ES |
dc.creator | Bueno-Lozano, Gloria | es_ES |
dc.creator | Moreno, Luis A. | es_ES |
dc.date.accessioned | 2023-10-26T14:26:33Z | |
dc.date.available | 2023-10-26T14:26:33Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Pérez-Gimeno, G., Seral-Cortes, M., Sabroso-Lasa, S., Esteban, L. M., Lurbe, E., Béghin, L., Gottrand, F., Meirhaeghe, A., Muntaner, M., Kafatos, A., Molnár, D., Leclercq, C., Widhalm, K., Kersting, M., Nova, E., Salazar-Tortosa, D. F., Gonzalez-Gross, M., Breidenassel, C., Sinningen, K., De Ruyter, T., Labayen, I., Rupérez, A. I., Bueno-Lozano, G., Moreno, L. A. (2023) Development of a genetic risk score to predict the risk of hypertension in european adolescents from the HELENA study. Frontiers in Cardiovascular Medicine, 10, 1-11. https://doi.org/10.3389/fcvm.2023.1118919. | en |
dc.identifier.issn | 2297-055X | |
dc.identifier.uri | https://hdl.handle.net/2454/46651 | |
dc.description.abstract | Introduction: From genome wide association study (GWAS) a large number of single nucleotide polymorphisms (SNPs) have previously been associated with blood pressure (BP) levels. A combination of SNPs, forming a genetic risk score (GRS) could be considered as a useful genetic tool to identify individuals at risk of developing hypertension from early stages in life. Therefore, the aim of our study was to build a GRS being able to predict the genetic predisposition to hypertension (HTN) in European adolescents. Methods: Data were extracted from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. A total of 869 adolescents (53% female), aged 12.5–17.5, with complete genetic and BP information were included. The sample was divided into altered (≥130 mmHg for systolic and/or ≥80 mmHg for diastolic) or normal BP. Based on the literature, a total of 1.534 SNPs from 57 candidate genes related with BP were selected from the HELENA GWAS database. Results: From 1,534 SNPs available, An initial screening of SNPs univariately associated with HTN (p < 0.10) was established, to finally obtain a number of 16 SNPs significantly associated with HTN (p < 0.05) in the multivariate model. The unweighted GRS (uGRS) and weighted GRS (wGRS) were estimated. To validate the GRSs, the area under the curve (AUC) was explored using ten-fold internal cross-validation for uGRS (0.802) and wGRS (0.777). Further covariates of interest were added to the analyses, obtaining a higher predictive ability (AUC values of uGRS: 0.879; wGRS: 0.881 for BMI z-score). Furthermore, the differences between AUCs obtained with and without the addition of covariates were statistically significant (p < 0.05). Conclusions: Both GRSs, the uGRS and wGRS, could be useful to evaluate the predisposition to hypertension in European adolescents. | en |
dc.description.sponsorship | The HELENA Study was financial support of the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034). GP-G, has receiving a predoctoral fellowship from the Government of Aragón. DFS-T was supported by a Marie S. Curie Global Fellowship within the European Union research and innovation framework programme (2014–2020; ClimAHealth: 101030971). MS-C has received funding from the Iberus Talent Pre-doctoral fellowships 2018, under the European Union's H2020 research and innovation programme under Marie Sklodowska-Curie grant agreement No. 801586. This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project “PI20/00988” and co-funded by the European Union. | en |
dc.format.mimetype | application/pdf | en |
dc.format.mimetype | application/msword | en |
dc.language.iso | eng | en |
dc.publisher | Frontiers Media | en |
dc.relation.ispartof | Frontiers in Cardiovascular Medicine 2023, 10: 1118919 | en |
dc.rights | © 2023 Pérez-Gimeno, Seral-Cortes, Sabroso-Lasa, Esteban, Lurbe, Béghin, Gottrand, Meirhaeghe, Muntaner, Kafatos, Molnár, Leclercq, Widhalm, Kersting, Nova, Salazar-Tortosa, Gonzalez-Gross, Breidenassel, Sinningen, De Ruyter, Labayen, Rupérez, Bueno-Lozano and Moreno. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adolescents | en |
dc.subject | Blood pressure | en |
dc.subject | Europe | en |
dc.subject | Genetic risk score | en |
dc.subject | Hypertension | en |
dc.subject | Prevention | en |
dc.title | Development of a genetic risk score to predict the risk of hypertension in european adolescents from the HELENA study | en |
dc.type | Artículo / Artikulua | es |
dc.type | info:eu-repo/semantics/article | en |
dc.date.updated | 2023-10-26T13:30:45Z | |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.contributor.department | Institute on Innovation and Sustainable Development in Food Chain - ISFOOD | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.doi | 10.3389/fcvm.2023.1118919 | |
dc.relation.projectID | info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/101030971 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/801586 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00988/ES/ | en |
dc.relation.publisherversion | https://doi.org/10.3389/fcvm.2023.1118919 | |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
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La licencia del ítem se describe como © 2023 Pérez-Gimeno, Seral-Cortes,
Sabroso-Lasa, Esteban, Lurbe, Béghin,
Gottrand, Meirhaeghe, Muntaner, Kafatos,
Molnár, Leclercq, Widhalm, Kersting, Nova,
Salazar-Tortosa, Gonzalez-Gross, Breidenassel,
Sinningen, De Ruyter, Labayen, Rupérez,
Bueno-Lozano and Moreno. This is an openaccess
article distributed under the terms of the
Creative Commons Attribution License (CC BY).