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dc.creatorRamírez, Hugoes_ES
dc.creatorReina Arias, Ramséses_ES
dc.creatorAmorena Zabalza, Beatrizes_ES
dc.creatorAndrés Cara, Damián dees_ES
dc.creatorMartínez, Humberto A.es_ES
dc.date.accessioned2018-10-02T07:58:02Z
dc.date.available2018-10-02T07:58:02Z
dc.date.issued2013
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/2454/30884
dc.description.abstractSmall ruminant lentiviruses (SRLV) cause a multisystemic chronic disease affecting animal production and welfare. SRLV infections are spread across the world with the exception of Iceland. Success in controlling SRLV spread depends largely on the use of appropriate diagnostic tools, but the existence of a high genetic/antigenic variability among these viruses, the fluctuant levels of antibody against them and the low viral loads found in infected individuals hamper the diagnostic efficacy. SRLV have a marked in vivo tropism towards the monocyte/macrophage lineage and attempts have been made to identify the genome regions involved in tropism, with two main candidates, the LTR and env gene, since LTR contains primer binding sites for viral replication and the env-encoded protein (SU ENV), which mediates the binding of the virus to the host’s cell and has hypervariable regions to escape the humoral immune response. Once inside the host cell, innate immunity may interfere with SRLV replication, but the virus develops counteraction mechanisms to escape, multiply and survive, creating a quasi-species and undergoing compartmentalization events. So far, the mechanisms of organ tropism involved in the development of different disease forms (neurological, arthritic, pulmonary and mammary) are unknown, but different alternatives are proposed. This is an overview of the current state of knowledge on SRLV genetic variability and its implications in tropism as well as in the development of alternative diagnostic assays.en
dc.format.extent33 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofViruses, 2013, 5, 1175-1207en
dc.rights© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license.en
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectSRLVen
dc.subjectCAEVen
dc.subjectVMVen
dc.subjectGenetic variabilityen
dc.subjectTropismen
dc.subjectDiagnosisen
dc.titleSmall ruminant lentiviruses: genetic variability, tropism and diagnosisen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentIdAB - Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.3390/v5041175
dc.relation.publisherversionhttps://doi.org/10.3390/v5041175en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


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© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license.
Except where otherwise noted, this item's license is described as © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license.