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The extradomain a of fibronectin enhances the efficacy of lipopolysaccharide defective Salmonella bacterins as vaccines in mice
(BioMed Central, 2012)
Artículo / Artikulua,
The Extradomain A from fibronectin (EDA) has an immunomodulatory role as fusion protein with viral and tumor antigens, but its effect when administered with bacteria has not been assessed. Here, we investigated the adjuvant ...
Salmonella biofilm development depends on the phosphorylation status of RcsB
(American Society for Microbiology, 2012)
Artículo / Artikulua,
The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric
bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...
Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host
(Public Library of Science, 2017)
info:eu-repo/semantics/article,
Many bacteria build biofilm matrices using a conserved exopolysaccharide named PGA or
PNAG (poly-β-1,6-N-acetyl-D-glucosamine). Interestingly, while E. coli and other members
of the family Enterobacteriaceae encode the ...
The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus
(Oxford University Press, 2018)
info:eu-repo/semantics/article,
RNA-binding proteins (RBPs) are essential to finetune
gene expression. RBPs containing the coldshock
domain are RNA chaperones that have been
extensively studied. However, the RNA targets and
specific functions for ...
Biofilm switch and immune response determinants at early stages of infection
(Elsevier (Cell Press), 2013)
Artículo / Artikulua,
Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose
(American Society for Microbiology, 2013)
Artículo / Artikulua,
Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
(American Society for Microbiology, 2014)
Artículo / Artikulua,
The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due
to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
Evaluation of a Salmonella strain lacking the secondary messenger c-di-GMP and RpoS as a live oral vaccine
(Public Library of Science, 2016)
Artículo / Artikulua,
Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through
the consumption of contaminated food, with chicken and pig related products being key reservoirs
of infection. Although numerous ...
Sensory deprivation in Staphylococcus aureus
(Springer Nature, 2018)
info:eu-repo/semantics/article,
Bacteria use two-component systems (TCSs) to sense and respond to environmental
changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16
TCSs, one of which (WalRK) is essential. Here we show ...
Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella
(National Academy of Sciences, 2009)
info:eu-repo/semantics/article,
Bacteria have developed an exclusive signal transduction system
involving multiple diguanylate cyclase and phosphodiesterase
domain-containing proteins (GGDEF and EAL/HD-GYP, respectively)
that modulate the levels of the ...