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Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins
dc.creator | Tormo Más, María Ángeles | es_ES |
dc.creator | Ferrer, María Desamparados | es_ES |
dc.creator | Maiques, Elisa | es_ES |
dc.creator | Ubeda, Carles | es_ES |
dc.creator | Selva, Laura | es_ES |
dc.creator | Lasa Uzcudun, Íñigo | es_ES |
dc.creator | Calvete, Juan J. | es_ES |
dc.creator | Novick, Richard P. | es_ES |
dc.creator | Penadés, José R. | es_ES |
dc.date.accessioned | 2019-01-23T11:16:22Z | |
dc.date.available | 2019-01-23T11:16:22Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0021-9193(Print) | |
dc.identifier.issn | 1098-5530 (Electronic) | |
dc.identifier.uri | https://hdl.handle.net/2454/32087 | |
dc.description.abstract | Staphylococcus aureus pathogenicity islands (SaPIs) have an intimate relationship with temperate staphylococcal phages. During phage growth, SaPIs are induced to replicate and are efficiently encapsidated into special small phage heads commensurate with their size. We have analyzed by amino acid sequencing and mass spectrometry the protein composition of the specific SaPI particles. This has enabled identification of major capsid and tail proteins and a putative portal protein. As expected, all these proteins were phage encoded. Additionally, these analyses suggested the existence of a protein required for the formation of functional phage but not SaPI particles. Mutational analysis demonstrated that the phage proteins identified were involved only in the formation and possibly the function of SaPI or phage particles, having no role in other SaPI or phage functions. | en |
dc.description.sponsorship | This work was supported by grant BIO2005-08399-C02-02 from the Comisión Interministerial de Ciencia y Tecnología (C.I.C.Y.T.) and grants from the Cardenal Herrera-CEU University and from the Generalitat Valenciana (ACOMP07/258) to J.R.P. Fellowship support for María Desamparados Ferrer and for Elisa Maiques from the Cardenal Herrera-CEU University is gratefully acknowledged. | en |
dc.format.extent | 7 p. | |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | American Society for Microbiology | en |
dc.relation.ispartof | Journal of Bacteriology, vol. 190, nº 7 , apr. 2008, p. 2434–2440 | en |
dc.rights | © 2008, American Society for Microbiology. All Rights Reserved. | en |
dc.subject | Staphylococcus aureus | en |
dc.subject | Staphylococcus Phages | en |
dc.subject | Viral proteins | en |
dc.subject | Genetics | en |
dc.title | Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.contributor.department | IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.identifier.doi | 10.1128/jb.01349-07 | |
dc.relation.publisherversion | https://doi.org/10.1128/jb.01349-07 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |