Person: Villanueva Larre, Arantxa
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Villanueva Larre
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Arantxa
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Ingeniería Eléctrica, Electrónica y de Comunicación
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ISC. Institute of Smart Cities
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0000-0001-9822-2530
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2247
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Publication Open Access Improved strategies for HPE employing learning-by-synthesis approaches(IEEE, 2018) Larumbe Bergera, Andoni; Ariz Galilea, Mikel; Bengoechea Irañeta, José Javier; Segura, Rubén; Cabeza Laguna, Rafael; Villanueva Larre, Arantxa; Ingeniería Eléctrica, Electrónica y de Comunicación; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio IngeniaritzarenThe first contribution of this paper is the presentation of a synthetic video database where the groundtruth of 2D facial landmarks and 3D head poses is available to be used for training and evaluating Head Pose Estimation (HPE) methods. The database is publicly available and contains videos of users performing guided and natural movements. The second and main contribution is the submission of a hybrid method for HPE based on Pose from Ortography and Scaling by Iterations (POSIT). The 2D landmark detection is performed using Random Cascaded-Regression Copse (R-CR-C). For the training stage we use, state of the art labeled databases. Learning-by-synthesis approach has been also used to augment the size of the database employing the synthetic database. HPE accuracy is tested by using two literature 3D head models. The tracking method proposed has been compared with state of the art methods using Supervised Descent Regressors (SDR) in terms of accuracy, achieving an improvement of 60%.Publication Open Access Contributions of artificial intelligence to low resolution renal multiparametric magnetic resonance analysis(2021) Oyarzun Domeño, Anne; Villanueva Larre, Arantxa; Ingeniería Eléctrica, Electrónica y de Comunicación; Institute of Smart Cities - ISC; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio IngeniaritzarenArterial spin labeling (ASL), is a Multiparametric Magnetic Resonance Imaging (MRI) technique used to quantify and evaluate Renal Blood Flow (RBF) and detect perfusion failure by labelling blood water as it flows throughout the kidney. This study aims at providing an automatic quantifying and evaluation tool for Chronic Kidney Disease (CKD) patients’s follow-up.Publication Open Access Optimizing interoperability between video-oculographic and electromyographic systems(Rehabilitation Research & Development Service, 2011) Navallas Irujo, Javier; Ariz Galilea, Mikel; Villanueva Larre, Arantxa; San Agustín, Javier; Cabeza Laguna, Rafael; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta ElektronikoaA new system is presented that enhances the interoperability between a video-oculographic (VOG) system for mouse movement control and an electromyographic (EMG) system for mouse click detection. The proposed VOG-EMG system combines gaze and muscle information to minimize the number of undesired clicks due to involuntary activations and environmental noise. We tested the system with 24 subjects, comparing three different configurations: one in which the VOG and EMG systems worked independently and two in which we used VOG gaze information to improve the EMG click detection. Results show that the number of false-positive click detections can be reduced when VOG and EMG information is combined. In addition, the third configuration, including extra processing, can reduce the activation delay produced because of the combined use of the VOG and EMG systems. The new VOG-EMG system is meant to be used in noisy environments in which the number of false clicks may impeach a reliable human-computer interaction.Publication Open Access Beyond basic tuning: exploring discrepancies in user and setup calibration for gaze estimation(ACM, 2024-06-04) Garde Lecumberri, Gonzalo; Armendáriz Armenteros, José María; Beruete Cerezo, Rubén; Cabeza Laguna, Rafael; Villanueva Larre, Arantxa; Ingeniería Eléctrica, Electrónica y de Comunicación; Ingeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio IngeniaritzaCalibrating gaze estimation models is crucial to maximize the effectiveness of these systems, although its implementation also poses challenges related to usability. Therefore, the simplification of this process is key. In this work, we dissect the impact of calibration due to both the environment and the user in gaze estimation models that employ general-purpose devices. We aim to replicate a workflow close to the final application by starting with pre-trained models and subsequently calibrating them using different strategies, testing under various camera arrangements and user-specific variability. The results indicate differentiation between the impact due to the user and the setup, being the components due to the users a slightly more pronounced impact than those related to the setup, opening the door to understanding calibration as a composite process. In any case, the development of calibration-free remote gaze estimation solutions remains a great challenge, given the crucial role of calibration.Publication Open Access SeTA: semiautomatic tool for annotation of eye tracking images(ACM, 2019) Larumbe Bergera, Andoni; Porta Cuéllar, Sonia; Cabeza Laguna, Rafael; Villanueva Larre, Arantxa; Ingeniería Eléctrica, Electrónica y de Comunicación; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio IngeniaritzarenAvailability of large scale tagged datasets is a must in the field of deep learning applied to the eye tracking challenge. In this paper, the potential of Supervised-Descent-Method (SDM) as a semiautomatic labelling tool for eye tracking images is shown. The objective of the paper is to evidence how the human effort needed for manually labelling large eye tracking datasets can be radically reduced by the use of cascaded regressors. Different applications are provided in the fields of high and low resolution systems. An iris/pupil center labelling is shown as example for low resolution images while a pupil contour points detection is demonstrated in high resolution. In both cases manual annotation requirements are drastically reduced.Publication Open Access Effects of a family-based lifestyle intervention plus supervised exercise training on abdominal fat depots in children with overweight or obesity: a secondary analysis of a nonrandomized clinical trial(American Medical Association, 2022) Cadenas-Sánchez, Cristina; Cabeza Laguna, Rafael; Idoate, Fernando; Osés Recalde, Maddi; Medrano Echeverría, María; Villanueva Larre, Arantxa; Arenaza Etxeberría, Lide; Sanz Muñoz, Aritz; Ortega, Francisco B.; Ruiz, Jonatan R.; Labayen Goñi, Idoia; Ciencias de la Salud; Ingeniería Eléctrica, Electrónica y de Comunicación; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD; Institute of Smart Cities - ISC; Osasun Zientziak; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio IngeniaritzarenImportance Excess abdominal fat is a major determinant in the development of insulin resistance and other metabolic disorders. Increased visceral adipose tissue (VAT) seems to precede the development of insulin resistance and is therefore a prime target of childhood lifestyle interventions aimed at preventing diabetes. OBJECTIVES To examine the effect of added exercise to a family-based lifestyle intervention program designed to reduce VAT plus subcutaneous (ASAT), intermuscular (IMAAT), and pancreatic (PAT) adipose tissue in children with overweight or obesity and to explore the effect of changes in VAT on insulin resistance. DESIGN, SETTING, AND PARTICIPANTS This 2-group, parallel-design clinical trial was conducted in Vitoria-Gasteiz, Spain. A total of 116 children with overweight or obesity participated and were assigned to a 22-week family-based lifestyle program (control group [n = 57]) or the same program plus an exercise intervention (exercise group [n = 59]). Data were collected between September 1, 2014, and June 30, 2017, and imaging processing for fat depot assessments and data analysis were performed between May 1, 2019, and February 12, 2021. INTERVENTIONS The compared interventions consisted of a family-based lifestyle and psychoeducation program (two 90-minute sessions per month) and the same program plus supervised exercise (three 90-minute sessions per week). MAIN OUTCOMES AND MEASURES The primary outcome of this study was the change in VAT between baseline and 22 weeks as estimated by magnetic resonance imaging. The secondary outcomes were changes in ASAT, IMAAT, and PAT. The effect of changes in VAT area on insulin resistance was also recorded. RESULTS The 116 participants included in the analysis (62 girls [53.4%]) had a mean (SD) age of 10.6 (1.1) years, and 67 (57.8%) presented with obesity. Significantly greater reductions were recorded for the exercise group in terms of reduction in VAT (−18.1% vs −8.5% for the control group; P = .004), ASAT (−9.9% vs −3.0%; P = .001), and IMAAT (−6.0% vs −2.6%; P = .02) fat fractions compared with the control group. Changes in VAT explained 87.6% of the improvement seen in insulin resistance (β = −0.102 [95% CI, −0.230 to −0.002]). CONCLUSIONS AND RELEVANCE These findings suggest that the addition of exercise to a lifestyle intervention program substantially enhanced the positive effects on abdominal fat depots in children with overweight or obesity. In addition, the reduction in VAT seemed to largely mediate the improvement of insulin sensitivity. These results highlight the importance of including exercise as part of lifestyle therapies aimed at treating childhood obesity and preventing the development of type 2 diabetes.Publication Open Access Diagnostic and prognostic potential of multiparametric renal MRI in Kidney transplant patients(Wiley, 2024) Echeverría Chasco, Rebeca; Martín Moreno, Paloma L.; Aramendía Vidaurreta, Verónica; García-Ruiz, Leyre; Mora-Gutiérrez, José María; Vidorreta Díaz de Cerio, Marta; Villanueva Larre, Arantxa; Cano, David; Bastarrika, Gorka; Fernández Seara, María A.; Ingeniería Eléctrica, Electrónica y de Comunicación; Institute of Smart Cities - ISC; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio IngeniaritzarenBackground: Multiparametric MRI provides assessment of functional and structural parameters in kidney allografts. Itoffers a non-invasive alternative to the current reference standard of kidney biopsy. Purpose: To evaluate the diagnostic and prognostic utility of MRI parameters in the assessment of allograft function in thefirst 3-months post-transplantation. Study Type: Prospective. Subjects: 32 transplant recipients (54 17 years, 20 females), divided into two groups according to estimated glomerularfiltration rate (eGFR) at 3-months post-transplantation: inferior graft function (IGF; eGFR<45 mL/min/1.73 m2,n=10) andsuperior graft function (SGF; eGFR≥45 mL/min/1.73 m2,n=22). Further categorization was based on the need for hemo-dialysis (C1) and decrease in s-creatinine (C2) at 1-week post-transplantation: delayed-graft-function (DGF:n=4 C1,n=10 C2) and early graft-function (EGF:n=28 C1,n=22 C2). Field Strength/Sequence: 3-T, pseudo-continuous arterial spin labeling, T1-mapping, and diffusion-weighted imaging. Assessment: Multiparametric MRI was evaluated at 1-week in all patients and 3-months after transplantation in 28 patients. Renalbloodflow (RBF), diffusion coefficients (ADC,ΔADC,D,ΔD,D*,flowing fractionf),T1andΔT1were calculated in cortex andmedulla. The diagnostic and prognostic value of these parameters, obtained at 3-months and 1-week post-transplantation,respectively, was evaluated in the cortex to discriminate between DGF and EGF, and between SGF and IGF. Statistical Tests: Logistic regression, receiver-operating-characteristics, area-under-the-curve (AUC), confidence intervals(CIs), analysis-of-variance,t-test, Wilcoxon-Mann–Whitney test, Fisher’s exact test, Pearson’s correlation.P-value<0.05 wasconsidered significant. Results: DGF patients exhibited significantly lower cortical RBF and f and higherD*. The diagnostic value of MRI fordetecting DGF was excellent (AUC=100%). Significant differences between patients with IGF and SGF were found inRBF,ΔT1, andΔD. Multiparametric MRI showed higher diagnostic (AUC=95.32%; CI: 88%–100%) and prognostic(AUC=97.47%, CI: 92%–100%) values for detecting IGF than eGFR (AUC=89.50%, CI: 79%–100%). Data Conclusion: Multiparametric MRI may show high diagnostic and prognostic value in transplanted patients, yieldingbetter results compared to eGFR measurements. Level of Evidence: 2. Technical Efficacy: Stage 1.Publication Open Access Multiparametric renal magnetic resonance imaging: a reproducibility study in renal allografts with stable function(Wiley, 2023) Echeverría Chasco, Rebeca; Martín Moreno, Paloma L.; Vidorreta, Marta; Aramendía Vidaurreta, Verónica; Cano, David; Villanueva Larre, Arantxa; Bastarrika, Gorka; Fernández Seara, María A.; García Fernández, Nuria; Ingeniería Eléctrica, Electrónica y de Comunicación; Institute of Smart Cities - ISC; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio IngeniaritzarenMonitoring renal allograft function after transplantation is key for the early detection of allograft impairment, which in turn can contribute to preventing the loss of the allograft. Multiparametric renal MRI (mpMRI) is a promising noninvasive technique to assess and characterize renal physiopathology; however, few studies have employed mpMRI in renal allografts with stable function (maintained function over a long time period). The purposes of the current study were to evaluate the reproducibility of mpMRI in transplant patients and to characterize normal values of the measured parameters, and to estimate the labeling efficiency of Pseudo-Continuous Arterial Spin Labeling (PCASL) in the infrarenal aorta using numerical simulations considering experimental measurements of aortic blood flow profiles. The subjects were 20 transplant patients with stable kidney function, maintained over 1 year. The MRI protocol consisted of PCASL, intravoxel incoherent motion, and T1 inversion recovery. Phase contrast was used to measure aortic blood flow. Renal blood flow (RBF), diffusion coefficient (D), pseudo-diffusion coefficient (D*), flowing fraction (f), and T1 maps were calculated and mean values were measured in the cortex and medulla. The labeling efficiency of PCASL was estimated from simulation of Bloch equations. Reproducibility was assessed with the within-subject coefficient of variation, intraclass correlation coefficient, and Bland-Altman analysis. Correlations were evaluated using the Pearson correlation coefficient. The significance level was p less than 0.05. Cortical reproducibility was very good for T1, D, and RBF, moderate for f, and low for D*, while medullary reproducibility was good for T1 and D. Significant correlations in the cortex between RBF and f (r = 0.66), RBF and eGFR (r = 0.64), and D* and eGFR (r = 0.57) were found. Normal values of the measured parameters employing the mpMRI protocol in kidney transplant patients with stable function were characterized and the results showed good reproducibility of the techniques.Publication Open Access Models for gaze tracking systems(Hindawi Publishing Corporation, 2007) Villanueva Larre, Arantxa; Cabeza Laguna, Rafael; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta ElektronikoaOne of the most confusing aspects that one meets when introducing oneself into gaze tracking technology is the wide variety, in terms of hardware equipment, of available systems that provide solutions to the same matter, that is, determining the point the subject is looking at. The calibration process permits generally adjusting nonintrusive trackers based on quite different hardware and image features to the subject. The negative aspect of this simple procedure is that it permits the system to work properly but at the expense of a lack of control over the intrinsic behavior of the tracker. The objective of the presented article is to overcome this obstacle to explore more deeply the elements of a video-oculographic system, that is, eye, camera, lighting, and so forth, from a purely mathematical and geometrical point of view. The main contribution is to find out the minimum number of hardware elements and image features that are needed to determine the point the subject is looking at. A model has been constructed based on pupil contour and multiple lighting, and successfully tested with real subjects. On the other hand, theoretical aspects of video-oculographic systems have been thoroughly reviewed in order to build a theoretical basis for further studies.Publication Open Access Accurate pupil center detection in off-the-shelf eye tracking systems using convolutional neural networks(MDPI, 2021) Larumbe Bergera, Andoni; Garde Lecumberri, Gonzalo; Porta Cuéllar, Sonia; Cabeza Laguna, Rafael; Villanueva Larre, Arantxa; Ingeniería Eléctrica, Electrónica y de Comunicación; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaRemote eye tracking technology has suffered an increasing growth in recent years due to its applicability in many research areas. In this paper, a video-oculography method based on convolutional neural networks (CNNs) for pupil center detection over webcam images is proposed. As the first contribution of this work and in order to train the model, a pupil center manual labeling procedure of a facial landmark dataset has been performed. The model has been tested over both real and synthetic databases and outperforms state-of-the-art methods, achieving pupil center estimation errors below the size of a constricted pupil in more than 95% of the images, while reducing computing time by a 8 factor. Results show the importance of use high quality training data and well-known architectures to achieve an outstanding performance.