Interplay of the mediterranean diet and genetic hypertension risk on blood pressure in european adolescents: findings from the HELENA study

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dc.contributor.authorPérez-Gimeno, Gloria
dc.contributor.authorSeral-Cortes, Miguel
dc.contributor.authorSabroso-Lasa, Sergio
dc.contributor.authorEsteban, Luis Mariano
dc.contributor.authorWidhalm, Kurt
dc.contributor.authorGottrand, Frédéric
dc.contributor.authorStehle, Peter
dc.contributor.authorMeirhaeghe, Aline
dc.contributor.authorMuntaner, Manon
dc.contributor.authorKafatos, Antonios
dc.contributor.authorGutiérrez, Ángel
dc.contributor.authorManios, Yannis
dc.contributor.authorAnastasiou, Costas A.
dc.contributor.authorGonzález Gross, Marcela
dc.contributor.authorBreidenassel, Christina
dc.contributor.authorCensi, Laura
dc.contributor.authorHenauw, Stefaan de
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorBueno-Lozano, Gloria
dc.contributor.authorRupérez, Azahara I.
dc.contributor.authorMoreno, Luis A.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2024-08-13T10:07:51Z
dc.date.available2024-08-13T10:07:51Z
dc.date.issued2024
dc.date.updated2024-08-13T10:02:17Z
dc.description.abstractEarly-life onset of high blood pressure is associated with the development of cardiovascular diseases in adulthood. In adolescents, limited evidence exists regarding the association between adherence to the Mediterranean Diet (MedDiet) and normal blood pressure (BP) levels, as well as its potential to modulate genetic predisposition to HTN. This study investigated the interaction between a MedDiet score and a recently developed HTN-genetic risk score (HTN-GRS) on blood pressure levels in a European adolescent cohort. The MedDiet score was derived from two non-consecutive 24-h dietary recalls and ranged from 0 (indicating low adherence) to 9 (indicating high adherence). Multiple linear regression models, adjusted for covariates, were employed to examine the relationship between the MedDiet score and BP z-scores and to assess the interaction effects between the MedDiet score and HTN-GRS on BP z-scores. MedDiet score showed a negative association with z-systolic BP (SBP) (ß = -0.40, p < 0.001) and z-diastolic BP (DBP) (ß = -0.29, p = 0.001). Additionally, a significant interaction effect was identified between the MedDiet score and HTN-GRS on z-SBP (ß = 0.02, p < 0.001) and z-DBP (ß = 0.02, p < 0.001). The modulatory effect of the MedDiet was more pronounced in females than in males, and HTN-GRS exhibited a stronger influence on DBP than on SBP. Conclusion: The study suggests that higher adherence to the MedDiet is associated with reduced BP levels in adolescents and provides evidence of a genetic-diet interaction influencing BP in adolescents. (Table presented.)en
dc.description.sponsorshipThe HELENA Study was the financial support of the European Community Sixth RTD Framework Programme (contract FOODCT-2005-007034).
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationPérez-Gimeno, G., Seral-Cortes, M., Sabroso-Lasa, S., Esteban, L. M., Widhalm, K., Gottrand, F., Stehle, P., Meirhaeghe, A., Muntaner, M., Kafatos, A., Gutierrez, A., Manios, Y., Anastasiou, C. A., Gonzalez-Gross, M., Breidenassel, C., Censi, L., de Henauw, S., Labayen, I., Bueno-Lozano, G., Rupérez, A. I., Moreno, L. A. (2024) Interplay of the mediterranean diet and genetic hypertension risk on blood pressure in european adolescents: findings from the HELENA study. European Journal of Pediatrics, 183(5), 2101-2110. https://doi.org/10.1007/s00431-024-05435-4.
dc.identifier.doi10.1007/s00431-024-05435-4
dc.identifier.issn0340-6199
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/50702
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Pediatrics (2024), vol. 183
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/801586/
dc.relation.publisherversionhttps://doi.org/10.1007/s00431-024-05435-4
dc.rights© The author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdolescentsen
dc.subjectGen-diet interactionen
dc.subjectGRSen
dc.subjectHypertensionen
dc.subjectMediterranean dieten
dc.titleInterplay of the mediterranean diet and genetic hypertension risk on blood pressure in european adolescents: findings from the HELENA studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscoveryb36e2b1d-3088-4089-806e-fd3040e9583a

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