Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: a randomized clinical trial

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dc.contributor.authorGil Cosano, José J.
dc.contributor.authorPlaza Florido, Abel
dc.contributor.authorGracia-Marco, Luis
dc.contributor.authorMigueles, Jairo H.
dc.contributor.authorCadenas-Sánchez, Cristina
dc.contributor.authorOlvera-Rojas, Marcos
dc.contributor.authorUbago Guisado, Esther
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorLucía, Alejandro
dc.contributor.authorOrtega, Francisco B.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2024-11-07T08:54:57Z
dc.date.available2024-11-07T08:54:57Z
dc.date.issued2024-07-31
dc.date.updated2024-11-07T08:37:54Z
dc.description.abstractBackground: we assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity. Methods: totally 109 participants (10.1±1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1β, IL-6, leptin, tumour necrosis factor-α and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined. Results: no intervention effect was found for any of the analysed biomarkers (all p≥0.05). We observed a significant sex by intervention interaction for IL-1β (p= 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1β levels (mean Z-score difference, 0.66 [95% confidence interval 0.32-1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1β (i.e., ≥0.2 standard deviations) than in the control group (15% vs. 85%, p=0.01). Conclusions: this exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.en
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades. Grant Numbers: DEP2013-47540, DEP2016-79512-R, DEP2017-91544-EXP. Universidad de Granada. Grant Number: SOMM17/6107/UGR. Instituto de Salud Carlos III. Grant Number: DEP2005-00046/ACTI. European Commission. Grant Number: 667302. Junta de Andalucía. Grant Number: B-CTS-355-UGR18. Ministerio de Educación, Cultura y Deporte. Grant Number: 09/UPB/19
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGil-Cosano, J. J., Plaza-Florido, A., Gracia-Marco, L., Migueles, J. H., Cadenas-Sanchez, C., Olvera-Rojas, M., Ubago-Guisado, E., Labayen, I., Lucia, A., Ortega, F. B. (2024). Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: a randomized clinical trial. Pediatric Obesity, 19(10), 1-14. https://doi.org/10.1111/ijpo.13152.
dc.identifier.doi10.1111/ijpo.13152
dc.identifier.issn2047-6310
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52461
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofPediatric Obesity (2024), vol. 19, núm. 10
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/667302/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2013-47540-R/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2016-79512-R/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2017-91544-EXP/
dc.relation.publisherversionhttps://doi.org/10.1111/ijpo.13152
dc.rights© 2024 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. This is an open access article under the terms of the Creative Commons Attribution License.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdipokinesen
dc.subjectCytokinesen
dc.subjectGrowth factorsen
dc.subjectPhysical exerciseen
dc.subjectYouthen
dc.titleEffects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: a randomized clinical trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationeeecebce-3369-4e9a-8372-894379eeaa96
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscoveryb36e2b1d-3088-4089-806e-fd3040e9583a

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