Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness

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dc.contributor.authorCadenas-Sánchez, Cristina
dc.contributor.authorMedrano Echeverría, María
dc.contributor.authorVillanueva Larre, Arantxa
dc.contributor.authorCabeza Laguna, Rafael
dc.contributor.authorIdoate, Fernando
dc.contributor.authorOsés Recalde, Maddi
dc.contributor.authorRodríguez Vigil, Beatriz
dc.contributor.authorÁlvarez de Eulate, Natalia
dc.contributor.authorAlberdi Aldasoro, Nerea
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentIngeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentIngeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzareneu
dc.date.accessioned2023-08-21T17:30:25Z
dc.date.available2023-08-21T17:30:25Z
dc.date.issued2023
dc.date.updated2023-08-21T17:00:47Z
dc.description.abstractObjectives: Fat depots localization has a critical role in the metabolic health status of adults. Nevertheless, whether that is also the case in children remains under- studied. Therefore, the aims of this study were: (i) to examine the differ-ences between metabolically healthy (MHO) and unhealthy (MUO) overweight/obesity phenotypes on specific abdominal fat depots, and (ii) to further explore whether cardiorespiratory fitness plays a major role in the differences between metabolic phenotypes among children with overweight/obesity. Methods: A total of 114 children with overweight/obesity (10.6 ±1.1 years, 62 girls) were included. Children were classified as MHO (n=68) or MUO. visceral (VAT), abdominal subcutaneous (ASAT), intermuscular abdominal (IMAAT), psoas, hepatic, pancreatic, and lumbar bone marrow adipose tissues were measured by magnetic resonance imaging. Cardiorespiratory fitness was assessed using the 20 m shuttle run test. Results: MHO children had lower VAT and ASAT contents and psoas fat fraction compared to MUO children (difference =12.4%– 25.8%, all p<0.035). MUO- unfit had more VAT and ASAT content than those MUO- fit and MHO- fit (difference =34.8%– 45.3%, all p<0.044). MUO- unfit shows also greater IMAAT fat fraction than those MUO- fit and MHO- fit peers (difference =16.4%– 13.9% respectively, all p≤0.001). In addition, MHO- unfit presented higher IMAAT fat fraction than MHO- fit (difference =13.4%, p<0.001). MUO- unfit presented higher psoas fat fraction than MHO- fit (difference =29.1%, p=0.008). Conclusions: VAT together with ASAT and psoas fat fraction, were lower in MHO than in MUO children. Further, we also observed that being fit, regardless of metabolic phenotype, has a protective role over the specific abdominal fat depots among children with overweight/obesity.en
dc.description.sponsorshipThis project was funded by the Spanish Ministry of Health “Fondos de Investigación Sanitaria del Instituto de Salud Carlos III” (PI13/01335), the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R), and by EU Fondos Estructurales de la Unión Europea (FEDER) funds (“Una manera de hacer Europa”). Support was also provided by the Department of Economic Development of the Government of Navarra (0011-1365-2019-000085). Dr Cadenas-Sanchez is supported by the Spanish Ministry of Science and Innovation (FJC2018-037925-I) and by a grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska Curie grant agreement No. 101028929. Dr Medrano is supported by the European Union NextGeneration EU and the Spanish Ministry of Universities (postdoctoral fellowship Margarita Salas, 572827-MS15). The other authors received no additional funding.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCadenas-Sanchez, C., Medrano, M., Villanueva, A., Cabeza, R., Idoate, F., Osés, M., Rodríguez-Vigil, B., Álvarez de Eulate, N., Alberdi Aldasoro, N., Ortega, F. B., Labayen, I. (2023) Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness. Scandinavian Journal of Medicine and Science in Sports, 1-11. https://doi.org/10.1111/sms.14372.en
dc.identifier.doi10.1111/sms.14372
dc.identifier.issn0905-7188
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45959
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofScandinavian Journal of Medicine and Science in Sports, 2023, 33(8), 1462–1472en
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/101028929/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F01335/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2016-78377-R/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FJC2018-037925-I/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1365-2019-000085/
dc.relation.publisherversionhttps://doi.org/10.1111/sms.14372
dc.rights© The Author(s) 2023. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAbdominal subcutaneous faten
dc.subjectAerobic capacityen
dc.subjectHepatic faten
dc.subjectLumbar bone marrow faten
dc.subjectPancreatic faten
dc.subjectPsoas faten
dc.subjectVisceral faten
dc.subjectYouthen
dc.titleDifferences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitnessen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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