Impact of 24-week supervised concurrent exercise on S-Klotho and vitamin D levels: a randomized controlled trial

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dc.contributor.authorAmaro Gahete, Francisco J.
dc.contributor.authorEspuch-Oliver, Andrea
dc.contributor.authorCano-Nieto, Amalia
dc.contributor.authorAlcántara Alcántara, Juan Manuel
dc.contributor.authorGarcía-Lario, José Vicente
dc.contributor.authorHaro Muñoz, Tomás de
dc.contributor.authorLlamas Elvira, José M.
dc.contributor.authorMuñoz Torres, Manuel
dc.contributor.authorCastillo, Manuel J.
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2025-02-26T10:43:29Z
dc.date.issued2025-01-20
dc.date.updated2025-02-26T10:16:32Z
dc.description.abstractThis study aimed to investigate the effects 24 weeks of supervised exercise training at different intensities on S-Klotho and 25-hydroxyvitamin D plasma levels in young adults. This report was based on a secondary analysis from the ACTIBATE single-center unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129). A total of 144 young adults (~34% men and ~66% women) aged between 18 and 25 years took part in the study. The participants were randomly assigned to 3 different groups: (i) concurrent exercise training program based on the international physical activity recommendations at vigorous intensity (Ex-Vigorous group), (ii) at moderate intensity (Ex-Moderate group), and (iii) control group (no exercise). S-Klotho and 25-hydroxyvitamin D plasma levels were determined before and after the 24-week intervention programme. A significant decrease of 25-hydroxyvitamin D plasma levels were identified across time in all groups (p < 0.001), whereas no significant differences across time were observed in S-Klotho plasma levels (p = 0.497). There was no time x group interaction neither in S-Klotho nor in 25-hydroxyvitamin D plasma levels (all p > 0.7). In summary, our results showed that 24 weeks of supervised concurrent exercise training does not induce significant changes on S-Klotho and 25-hydroxyvitamin D independently of the exercise intensity in young adults.en
dc.description.sponsorshipThis study was funded by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III [PI13/01393; J.R.R.] and PTA-12264I, Retos de la Sociedad[DEP2016-79512-R; J.R.R.] and European Regional Development Funds(ERDF; J.R.R.), the Spanish Ministry of Education (FPU14/04172 (F.A.G.) andFPU15/04059 (J.M.A.)), the Fundación Iberoamericana de Nutrición (FINUT;JRR), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMIDRD16/0022; J.R.R.), the AstraZeneca HealthCare Foundation (J.R.R.), the University of Granada Plan Propio de Investigación 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES) (J.R.R.), the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF; ref. SOMM17/6107/UGR; JRR), the Junta de Andalucía, Consejería de Economía, Conocimiento, Empresas y Universidad (ref. P18-RT-4455; J.R.R.), the Juan de la Cierva-Formación Grant funded by MCIN/AEI/ 10.13039/501100011033 and by 'EuropeanUnion NextGenerationEU/ PRTR' (Ref. FJC2020-044453-I; J.M.A.).
dc.embargo.lift2026-01-20
dc.embargo.terms2026-01-20
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationAmaro-Gahete, F. J., Espuch-Oliver, A., Cano-Nieto, A., Alcantara, J. M. A., García-Lario, J. V., De Haro, T., Llamas-Elvira, J. M., Muñoz Torres, M., Castillo, M. J., Labayen, I., Ruiz, J. R. (2024). Impact of 24-week supervised concurrent exercise on S-Klotho and vitamin D levels: a randomized controlled trial. Journal of Sports Sciences, 42(24), 2562-2571. https://doi.org/10.1080/02640414.2025.2453328.
dc.identifier.doi10.1080/02640414.2025.2453328
dc.identifier.issn0264-0414
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53580
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofJournal of Sports Sciences (2024), vol. 42, núm. 24
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F01393/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement///PTA-12264/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI//DEP2016-79512-R/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU14%2F04172/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU15%2F04059/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//RD16%2F0022%2F0003/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FJC2020-044453-I/
dc.relation.publisherversionhttps://doi.org/10.1080/02640414.2025.2453328
dc.rights© 2025 Informa UK Limited, trading as Taylor & Francis Group. This is an Accepted Manuscript version and it is deposited under the terms of the Creative Commons Attribution-NonCommercial License.
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAerobic trainingen
dc.subjectConcurrent trainingen
dc.subjectExercise physiologyen
dc.subjectStrength trainingen
dc.titleImpact of 24-week supervised concurrent exercise on S-Klotho and vitamin D levels: a randomized controlled trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication81010fc5-9a1b-44dd-8cfe-933acda93159
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscovery81010fc5-9a1b-44dd-8cfe-933acda93159

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