Effects of early, late and self-selected time-restricted eating on visceral adipose tissue and cardiometabolic health in participants with overweight or obesity: a randomized controlled trial

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dc.contributor.authorDote-Montero, Manuel
dc.contributor.authorClavero-Jimeno, Antonio
dc.contributor.authorMerchán Ramírez, Elisa
dc.contributor.authorOsés Recalde, Maddi
dc.contributor.authorEcharte Medina, Jon
dc.contributor.authorCamacho-Cardenosa, Alba
dc.contributor.authorConcepción Álvarez, Mara de la Caridad
dc.contributor.authorAmaro Gahete, Francisco J.
dc.contributor.authorAlcántara Alcántara, Juan Manuel
dc.contributor.authorLópez-Vázquez, Alejandro
dc.contributor.authorCupeiro, Rocío
dc.contributor.authorMigueles, Jairo H.
dc.contributor.authorDe la O, Alejandro
dc.contributor.authorGarcía Pérez, Patricia Virginia
dc.contributor.authorContreras-Bolivar, Victoria
dc.contributor.authorMuñoz-Garach, Araceli
dc.contributor.authorZugasti Murillo, Ana
dc.contributor.authorPetrina Jáuregui, María Estrella
dc.contributor.authorÁlvarez de Eulate, Natalia
dc.contributor.authorGoñi Gironés, María Elena
dc.contributor.authorArmendáriz Brugos, Cristina
dc.contributor.authorGonzález Cejudo, María Trinidad
dc.contributor.authorMartín-Rodríguez, José L.
dc.contributor.authorIdoate, Fernando
dc.contributor.authorCabeza Laguna, Rafael
dc.contributor.authorCarneiro-Barrera, Almudena
dc.contributor.authorCabo, Rafael de
dc.contributor.authorMuñoz Torres, Manuel
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.contributor.departmentIngeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.departmentIngeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritzaeu
dc.contributor.departmentAgronomía, Biotecnología y Alimentaciónes_ES
dc.contributor.departmentAgronomia, Bioteknologia eta Elikaduraeu
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2025-02-26T15:46:31Z
dc.date.issued2025-01-07
dc.date.updated2025-02-26T15:11:21Z
dc.description.abstractThe optimal eating window for time-restricted eating (TRE) remains unclear, particularly its impact on visceral adipose tissue (VAT), which is associated with cardiometabolic morbidity and mortality. We investigated the effects of three TRE schedules (8 h windows in the early day, late day and participant-chosen times) combined with usual care (UC, based on education about the Mediterranean diet) versus UC alone over 12 weeks in adults with overweight or obesity. The primary outcome was VAT changes measured by magnetic resonance imaging. A total of 197 participants were randomized to UC (n = 49), early TRE (n = 49), late TRE (n = 52) or self-selected TRE (n = 47). No significant differences were found in VAT changes between early TRE (mean difference (MD): −4%; 95% confidence interval (CI), −12 to 4; P = 0.87), late TRE (MD: −6%; 95% CI, −13 to 2; P = 0.31) and self-selected TRE (MD: −3%; 95% CI, −11 to 5; P ≥ 0.99) compared with UC, nor among the TRE groups (all P ≥ 0.99). No serious adverse events occurred; five participants reported mild adverse events. Adherence was high (85–88%) across TRE groups. These findings suggest that adding TRE, irrespective of eating window timing, offers no additional benefit over a Mediterranean diet alone in reducing VAT. TRE appears to be a safe, well-tolerated and feasible dietary approach for adults with overweight or obesity. ClinicalTrials.gov registration: NCT05310721.en
dc.description.sponsorshipThis study (project reference PID2022.141506OB.I00) is funded by the MCIU/AEI /10.13039/501100011033 and by ERDF EU A Way of Making Europe to J.R.R.; Junta de Andalucía, Consejería de Transformación económica, Industria, Conocimiento y Universidades (A-CTS-516-UGR20) to J.R.R.; the University of Granada Plan Propio de Investigación-Excellence actions: Unit of Excellence on Exercise Nutrition and Health (UCEENS) to J.R.R.; the Consejo Superior de Deportes, Ministerio de Cultura y Deporte (project reference EXP_75091), Plan de Recuperación, Transformación y Resiliencia -Funded by the European Union NextGenerationEU to I.L.; the Government of Navarra, Departamento de Desarrollo Económico y Empresarial (0011-1365-2021-00070), Plan de Promoción de Grupos de Investigación de la Universidad Pública de Navarra to I.L.; Juan de la Cierva Formación (FJC2020-044453-I to J.M.A.A. and FJC2020-043385-I to A.C.-C.) funded by the Ministerio de Ciencia e Innovación and by the European Union NextGenerationEU/PRTR; Recualification of the Spanish University System 2021-2023 from the Spanish Ministry of Universities (RD 289/2021 to R. Cupeiro), funded by the European Union NextGenerationEU; Spanish Ministry of Universities (FPU 18/03357 to M.D.-M. and FPU21/01161 to A.C.J.); Spanish Ministry of Science, Innovation and Universities under Beatriz Galindo's 2022 fellowship program (ref: BG22/00075 to J.H.M.). In addition, funding was provided from the EXERNET Research Network on Exercise and Health (DEP2005-00046/ACTI; 09/UPB/19; 45/UPB/20; 27/UPB/21 to I.L. and J.R.R.). R.d.C. is funded through the Intramural Research Program of the National Institute on Aging. This work is part of a doctorate thesis conducted in the Official Doctoral Program in Biomedicine of the University of Granada, Spain.
dc.embargo.lift2025-07-07
dc.embargo.terms2025-07-07
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.citationDote-Montero, M., Clavero-Jimeno, A., Merchán-Ramírez, E., Oses, M., Echarte, J., Camacho-Cardenosa, A., Concepción, M., Amaro-Gahete, F. J., Alcántara, J. M. A., López-Vázquez, A., Cupeiro, R., Migueles, J. H., De-la-O, A., García Pérez, P. V., Contreras-Bolivar, V., Muñoz-Garach, A., Zugasti, A., Petrina, E., Alvarez de Eulate, N., Goñi, E., Armendariz-Brugos, C., González Cejudo, M. T., Martín-Rodríguez, J. L., Idoate, F., Cabeza, R., Carneiro-Barrera, A., Cabo, R. de, Muñoz-Torres, M., Labayen, I., Ruiz, J. R. (2025) Effects of early, late and self-selected time-restricted eating on visceral adipose tissue and cardiometabolic health in participants with overweight or obesity: a randomized controlled trial. Nature Medicine. https://doi.org/10.1038/s41591-024-03375-y.
dc.identifier.doi10.1038/s41591-024-03375-y
dc.identifier.issn1078-8956
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53584
dc.language.isoeng
dc.publisherNature Research
dc.relation.ispartofNature Medicine, 31, 524–533, (2025)
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-141506OB-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1365-2021-00070/
dc.relation.publisherversionhttps://doi.org/10.1038/s41591-024-03375-y
dc.rights© 2025, The Author(s), under exclusive licence to Springer Nature America, Inc.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectAdulten
dc.subjectDiet Mediterraneanen
dc.subjectFastingen
dc.subjectFemaleen
dc.subjectIntra-abdominal faten
dc.subjectDiagnostic imagingen
dc.subjectMagnetic resonance imagingen
dc.subjectMiddle ageden
dc.subjectObesityen
dc.subjectDiet therapyen
dc.subjectOverweighen
dc.subjectTime factorsen
dc.titleEffects of early, late and self-selected time-restricted eating on visceral adipose tissue and cardiometabolic health in participants with overweight or obesity: a randomized controlled trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
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