Development of a genetic risk score to predict the risk of hypertension in european adolescents from the HELENA study

Simple item page
dc.contributor.authorPérez-Gimeno, Gloria
dc.contributor.authorSeral-Cortes, Miguel
dc.contributor.authorSabroso-Lasa, Sergio
dc.contributor.authorEsteban, Luis Mariano
dc.contributor.authorLurbe, Empar
dc.contributor.authorBéghin, Laurent
dc.contributor.authorGottrand, Frédéric
dc.contributor.authorMeirhaeghe, Aline
dc.contributor.authorMuntaner, Manon
dc.contributor.authorKafatos, Antonios
dc.contributor.authorMolnár, Dénes
dc.contributor.authorLeclercq, Catherine
dc.contributor.authorWidhalm, Kurt
dc.contributor.authorKersting, Mathilde
dc.contributor.authorNova, Esther
dc.contributor.authorSalazar-Tortosa, Diego
dc.contributor.authorGonzález Gross, Marcela
dc.contributor.authorBreidenassel, Christina
dc.contributor.authorSinningen, Kathrin
dc.contributor.authorRuyter, Thaïs de
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorRupérez, Azahara I.
dc.contributor.authorBueno-Lozano, Gloria
dc.contributor.authorMoreno, Luis A.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2023-10-26T14:26:33Z
dc.date.available2023-10-26T14:26:33Z
dc.date.issued2023
dc.date.updated2023-10-26T13:30:45Z
dc.description.abstractIntroduction: From genome wide association study (GWAS) a large number of single nucleotide polymorphisms (SNPs) have previously been associated with blood pressure (BP) levels. A combination of SNPs, forming a genetic risk score (GRS) could be considered as a useful genetic tool to identify individuals at risk of developing hypertension from early stages in life. Therefore, the aim of our study was to build a GRS being able to predict the genetic predisposition to hypertension (HTN) in European adolescents. Methods: Data were extracted from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. A total of 869 adolescents (53% female), aged 12.5–17.5, with complete genetic and BP information were included. The sample was divided into altered (≥130 mmHg for systolic and/or ≥80 mmHg for diastolic) or normal BP. Based on the literature, a total of 1.534 SNPs from 57 candidate genes related with BP were selected from the HELENA GWAS database. Results: From 1,534 SNPs available, An initial screening of SNPs univariately associated with HTN (p < 0.10) was established, to finally obtain a number of 16 SNPs significantly associated with HTN (p < 0.05) in the multivariate model. The unweighted GRS (uGRS) and weighted GRS (wGRS) were estimated. To validate the GRSs, the area under the curve (AUC) was explored using ten-fold internal cross-validation for uGRS (0.802) and wGRS (0.777). Further covariates of interest were added to the analyses, obtaining a higher predictive ability (AUC values of uGRS: 0.879; wGRS: 0.881 for BMI z-score). Furthermore, the differences between AUCs obtained with and without the addition of covariates were statistically significant (p < 0.05). Conclusions: Both GRSs, the uGRS and wGRS, could be useful to evaluate the predisposition to hypertension in European adolescents.en
dc.description.sponsorshipThe HELENA Study was financial support of the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034). GP-G, has receiving a predoctoral fellowship from the Government of Aragón. DFS-T was supported by a Marie S. Curie Global Fellowship within the European Union research and innovation framework programme (2014–2020; ClimAHealth: 101030971). MS-C has received funding from the Iberus Talent Pre-doctoral fellowships 2018, under the European Union's H2020 research and innovation programme under Marie Sklodowska-Curie grant agreement No. 801586. This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project “PI20/00988” and co-funded by the European Union.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationPérez-Gimeno, G., Seral-Cortes, M., Sabroso-Lasa, S., Esteban, L. M., Lurbe, E., Béghin, L., Gottrand, F., Meirhaeghe, A., Muntaner, M., Kafatos, A., Molnár, D., Leclercq, C., Widhalm, K., Kersting, M., Nova, E., Salazar-Tortosa, D. F., Gonzalez-Gross, M., Breidenassel, C., Sinningen, K., De Ruyter, T., Labayen, I., Rupérez, A. I., Bueno-Lozano, G., Moreno, L. A. (2023) Development of a genetic risk score to predict the risk of hypertension in european adolescents from the HELENA study. Frontiers in Cardiovascular Medicine, 10, 1-11. https://doi.org/10.3389/fcvm.2023.1118919.en
dc.identifier.doi10.3389/fcvm.2023.1118919
dc.identifier.issn2297-055X
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46651
dc.language.isoengen
dc.publisherFrontiers Mediaen
dc.relation.ispartofFrontiers in Cardiovascular Medicine 2023, 10: 1118919en
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/101030971/
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/801586/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00988/ES/
dc.relation.publisherversionhttps://doi.org/10.3389/fcvm.2023.1118919
dc.rights© 2023 Pérez-Gimeno, Seral-Cortes, Sabroso-Lasa, Esteban, Lurbe, Béghin, Gottrand, Meirhaeghe, Muntaner, Kafatos, Molnár, Leclercq, Widhalm, Kersting, Nova, Salazar-Tortosa, Gonzalez-Gross, Breidenassel, Sinningen, De Ruyter, Labayen, Rupérez, Bueno-Lozano and Moreno. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY).en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdolescentsen
dc.subjectBlood pressureen
dc.subjectEuropeen
dc.subjectGenetic risk scoreen
dc.subjectHypertensionen
dc.subjectPreventionen
dc.titleDevelopment of a genetic risk score to predict the risk of hypertension in european adolescents from the HELENA studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscoveryb36e2b1d-3088-4089-806e-fd3040e9583a

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Perez_DevelopmentGenetic.pdf
Size:
641.67 KB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Perez_DevelopmentGenetic_MatCompl.docx
Size:
6.49 MB
Format:
Microsoft Word XML
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.78 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DCS - OZS Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak
Artículos de revista ISFOOD - ISFOOD aldizkari artikuluak
Investigaciones financiadas por la Unión Europea (OpenAire) - Europar Batasunak finantzatutako ikerketak (OpenAire)