Publication:
Omics approaches in pancreatic adenocarcinoma

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Date

2019

Authors

González Borja, Iranzu
Viúdez, Antonio
Carrasco García, Estefanía
Pérez Sanz, Jairo
Hernández García, Irene

Director

Publisher

MDPI
Acceso abierto / Sarbide irekia
Artículo / Artikulua
Versión publicada / Argitaratu den bertsioa

Project identifier

Abstract

Pancreatic ductal adenocarcinoma, which represents 80% of pancreatic cancers, is mainly diagnosed when treatment with curative intent is not possible. Consequently, the overall five-year survival rate is extremely dismal—around 5% to 7%. In addition, pancreatic cancer is expected to become the second leading cause of cancer-related death by 2030. Therefore, advances in screening, prevention and treatment are urgently needed. Fortunately, a wide range of approaches could help shed light in this area. Beyond the use of cytological or histological samples focusing in diagnosis, a plethora of new approaches are currently being used for a deeper characterization of pancreatic ductal adenocarcinoma, including genetic, epigenetic, and/or proteo-transcriptomic techniques. Accordingly, the development of new analytical technologies using body fluids (blood, bile, urine, etc.) to analyze tumor derived molecules has become a priority in pancreatic ductal adenocarcinoma due to the hard accessibility to tumor samples. These types of technologies will lead us to improve the outcome of pancreatic ductal adenocarcinoma patients.

Description

Keywords

Pancreatic adenocarcinoma, CtDNA, Proteomic, Genomic, Metabolomic, Lipidomic, FFPE, Tissue, Body fluids

Department

Ciencias de la Salud / Osasun Zientziak

Faculty/School

Degree

Doctorate program

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