Publication:
Revisiting skeletal myopathy and exercise training in heart failure: emerging role of myokines

Date

2023

Authors

González, Arantxa
Latasa Amézqueta, Íñigo
Díez, Javier

Director

Publisher

Elsevier
Acceso abierto / Sarbide irekia
Artículo / Artikulua
Versión publicada / Argitaratu den bertsioa

Project identifier

MINECO//CB16%2F11%2F00483/ES/recolecta
ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01469/ES/recolecta
AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113098RB-I00/ES/recolecta
European Commission/Horizon 2020 Framework Programme/848109openaire
Métricas Alternativas

Abstract

Exercise intolerance remains a major unmet medical need in patients with heart failure (HF). Skeletal myopathy is currently considered as the major limiting factor for exercise capacity in HF patients. On the other hand, emerging evidence suggest that physical exercise can decrease morbidity and mortality in HF patients. Therefore, mechanistic insights into skeletal myopathy may uncover critical aspects for therapeutic interventions to improve exercise performance in HF. Emerging data reviewed in this article suggest that the assessment of circulating myokines (molecules synthesized and secreted by skeletal muscle in response to contraction that display autocrine, paracrine and endocrine actions) may provide new insights into the pathophysiology, phenotyping and prognostic stratification of HF-related skeletal myopathy. Further studies are required to determine whether myokines may also serve as biomarkers to personalize the modality and dose of physical training prescribed for patients with HF and exercise intolerance. In addition, the production and secretion of myokines in patients with HF may interact with systemic alterations (e.g., inflammation and metabolic disturbances), frequently present in patients with HF. Furthermore, myokines may exert beneficial or detrimental effects on cardiac structure and function, which may influence adverse cardiac remodelling and clinical outcomes in HF patients. Collectively, these data suggest that a deeper knowledge on myokines regulation and actions may lead to the identification of novel physical exercise-based therapeutic approaches for HF patients.

Description

Keywords

Heart failure, Skeletal myopathy, Physical exercise, Myokines, Biomarkers, Personalized training

Department

Ciencias de la Salud / Osasun Zientziak

Faculty/School

Degree

Doctorate program

item.page.cita

Ramírez-Vélez R., González, A.,, García-Hermoso, A., Amézqueta, I. L., Izquierdo, M., Díez, J. (2023) Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines. Metabolism, 138, 1-10. https://doi.org/10.1016/j.metabol.2022.155348.

item.page.rights

© 2022 The Authors. This is an open access article under the CC BY-NC-ND license.

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